PubMed · 4402180
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
O J Malm. 1972-04-20. [Rejection reaction].. https://pubmed.ncbi.nlm.nih.gov/4402180/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
Recognition of the importance of immune cells present in a hematopoietic graft has resulted in a significant change in the perception of allogeneic hematopoietic transplantation. Such a transplant modality is now perceived has a very efficient form of adoptive allogeneic immunotherapy unfortunately associated with significant toxicity.
The pathology of cutaneous T-cell lymphomas is predominantly in the skin. Allogeneic bone-marrow transplantation results in graft-versus-host disease involving the skin in many cases. It has been suggested that it would be interesting to see the effect of allotransplantation, even though no series has been reported so far. Adoptive immunotherapy with donor lymphocyte infusions has been increasingly used to treat post-transplant relapse and even prevention. The present hypothesis suggests that infusion of human leucocyte antigen (HLA)-matched donor lymphocyte infusions would result in a graft-versus-leukemia/lymphoma (GVL) effect in these disorders. Therefore, clinical trials are suggested.