Longitudinal Prediction of Retinal Sensitivity Based on Disease Progression Quantified From Optical Coherence Tomography in Geographic Atrophy.

Klaudia Birner; Julia Mai; Daniela Boryshchuk; Florian Frommlet; Roy Schwartz; Simon Sch&#xfc;rer-Waldheim; Oliver Leingang; Wolf Dieter-Vogl; Ursula Schmidt-Erfurth

doi:10.1167/iovs.67.11.28

PubMed · 42742213

Longitudinal Prediction of Retinal Sensitivity Based on Disease Progression Quantified From Optical Coherence Tomography in Geographic Atrophy.

Klaudia Birner·Julia Mai·Daniela Boryshchuk·Florian Frommlet·Roy Schwartz·Simon Schürer-Waldheim·Oliver Leingang·Wolf Dieter-Vogl·Ursula Schmidt-Erfurth

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Abstract

PURPOSE: The purpose of this study was to analyze the association between disease progression of geographic atrophy (GA) from optical coherence tomography (OCT) with retinal sensitivity (RS) in microperimetry (MP) over a 2-year follow-up period. METHODS: This is a longitudinal analysis of the OAKS Phase-III clinical trial. Both study and fellow eyes with GA that underwent imaging with the Spectralis OCT and consecutive MP examination were eligible. Pointwise quantification of ellipsoid zone (EZ) thickness, EZ and retinal pigment epithelium (RPE) loss from OCT volumes was correlated with localized RS. A longitudinal predictive model using a Markov Chain framework was implemented to predict RS change over time based on OCT biomarkers. The modeling of morphological and functional progression was based on the fellow-eye cohort. RESULTS: A total of 39,681 MP points from 406 patients were analyzed. In the fellow eye cohort, baseline (BSL) EZ thickness was positively associated with RS (0.3 decibel [dB]/µm, P < 0.001). Decrease in EZ thickness between visits during follow-up was significantly associated with decrease in RS (0.1 dB / 1 µm change). RS was significantly lower in MP points within EZ loss during follow-up compared with MP points within the retina with measurable EZ (P < 0.001). The largest functional decline was observed within RPE loss, also associated with the highest probability of absolute scotoma (P < 0.001). Morphological progression to EZ and RPE loss was influenced by EZ thickness and the morphology of adjacent MP points (P < 0.001). CONCLUSIONS: Two exploratory endpoints were developed, namely quantification of EZ thickness and loss, and localized RS within high-risk OCT areas. RS decline during follow-up is associated with automatically quantified disease progression in OCT.

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Humans Tomography, Optical Coherence Geographic Atrophy Disease Progression Female Male Aged Visual Field Tests Follow-Up Studies Retinal Pigment Epithelium Visual Fields Retina Visual Acuity Middle Aged Journal Article Clinical Trial, Phase III Randomized Controlled Trial Multicenter Study

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Klaudia Birner, Julia Mai, Daniela Boryshchuk, Florian Frommlet, Roy Schwartz, Simon Schürer-Waldheim, Oliver Leingang, Wolf Dieter-Vogl, Ursula Schmidt-Erfurth. 2026-09-01. Longitudinal Prediction of Retinal Sensitivity Based on Disease Progression Quantified From Optical Coherence Tomography in Geographic Atrophy.. https://doi.org/10.1167/iovs.67.11.28

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Aged subject Clinical Trial, Phase III subject Female subject Follow-Up Studies subject Humans subject Journal Article subject Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study resource Male subject Middle Aged subject Multicenter Study subject Randomized controlled trials study disease progression subject

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