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PubMed · 42735679

Pancreatic ductal adenocarcinoma: The Vision of Heracles.

Carmen Mota Reyes·Mara R Goetz·Hana Algül·Alper Dogruoez·Chiara Falcomatà·Matthias M Gaida·Kıvanç Görgülü·Yetiş Gültekin·Ibrahim Halil Gürcinar·Marie C Hasselluhn·Rouzanna Istvanffy·Raghu Kalluri·Valerie S Kalluri·Ashley Kiemen·Pilhan Kim·Sang-Won Lee·Marina Lesina·Peter Yu·Anirban Maitra·Clara M Müller·Sebastian Müller·Dowoon Nam·Kenneth P Olive·Marina Pasca Di Magliano·Roland Rad·Dieter Saur·Matthew G Vander Heiden·Mathias Vormehr·Laura D Wood·Eyüp Yöndem·David Zschäpitz·Didem Karakas·Helmut Friess·Güralp O Ceyhan·European Pancreatic Club (EPC) Pancreatic Cancer Think Tank Group·Ihsan Ekin Demir
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest malignancies, as tumors evolve faster than therapies. Resistance is ecological, not merely KRAS driven, involving overlooked players like high-grade pancreatic intraepithelial neoplasias (PanINs), peripancreatic fat, stromal mechanics, myeloid-neural circuits, metabolic rewiring, and systemic host responses. We propose precision interception targeting PanIN/intraductal papillary mucinous neoplasm (IPMN) biology, spatial-functional-proteogenomic classification beyond transcriptomics, the Heracles Protocol (measure, prime, strike, and adapt), and integrated technologies from AI pathology to exosomal delivery and CRISPR-based synergy mapping, together making PDAC more tractable.

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HumansCarcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsJournal ArticleReview

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BibTeXRIS

Carmen Mota Reyes, Mara R Goetz, Hana Algül, Alper Dogruoez, Chiara Falcomatà, Matthias M Gaida, Kıvanç Görgülü, Yetiş Gültekin, Ibrahim Halil Gürcinar, Marie C Hasselluhn, Rouzanna Istvanffy, Raghu Kalluri, Valerie S Kalluri, Ashley Kiemen, Pilhan Kim, Sang-Won Lee, Marina Lesina, Peter Yu, Anirban Maitra, Clara M Müller, Sebastian Müller, Dowoon Nam, Kenneth P Olive, Marina Pasca Di Magliano, Roland Rad, Dieter Saur, Matthew G Vander Heiden, Mathias Vormehr, Laura D Wood, Eyüp Yöndem, David Zschäpitz, Didem Karakas, Helmut Friess, Güralp O Ceyhan, European Pancreatic Club (EPC) Pancreatic Cancer Think Tank Group, Ihsan Ekin Demir. 2026-09-14. Pancreatic ductal adenocarcinoma: The Vision of Heracles.. https://doi.org/10.1016/j.ccell.2026.07.014

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