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Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives.

Tomas Formanek·Mary-Ellen Lynall·Emanuele Felice Osimo
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Abstract

Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodological approaches - from target trial emulation on observational data to functional genomics - offer a potential path towards precision immunopsychiatry and stratified immunomodulatory treatment.

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Neuroimmunologydepressive disordersmolecular biologyneurosciencepsychotic disorders/schizophreniaJournal Article

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Tomas Formanek, Mary-Ellen Lynall, Emanuele Felice Osimo. 2026-09-08. Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives.. https://doi.org/10.1192/bjp.2026.10761

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