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Acceptability of alcohol-based hand rub during neonatal care in rural Ugandan households: a qualitative study nested within the BabyGel trial.

Heidi H Thorsdalen·Ingunn Marie S Engebretsen·David Mukunya·Vivian Mutaki·Agnes Napyo·Thorkild Tylleskär·Andrew Weeks·Melf-Jakob Kühl
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Abstract

BACKGROUND: Poor access to water, sanitation and hygiene exacerbates the spread of infections among newborns. The BabyGel cluster randomised trial assessed the effectiveness of a community-level alcohol-based hand rub with a training component in reducing infection or death rates among newborns in Uganda. OBJECTIVE: Nested in the BabyGel trial, this study investigated the acceptability of the BabyGel intervention among mothers and household members in Eastern Uganda, using the Theoretical Framework of Acceptability. METHODS: In 2022, we conducted individual semistructured interviews with mothers, and group interviews with mothers and other household members, all recruited from intervention-arm clusters. Thematic analysis combined inductive and deductive coding, structured by the framework's seven constructs: affective attitude, burden, ethicality, intervention coherence, opportunity costs, perceived effectiveness and self-efficacy. RESULTS: Twenty mothers and 14 household members participated in 10 individual and 10 small group interviews. Participants found the intervention generally acceptable, appreciating its convenience and perceived protection against infection. Many described hand hygiene changes that persisted beyond the intervention period. However, concerns related to its harmful effects, spiritual beliefs and social tensions with visitors occasionally influenced its use. CONCLUSION: Alcohol-based hand rub combined with a training component was generally well accepted, driven by perceived health and practical benefits, although concerns related to safety, belief systems and social dynamics remained. Because data collection coincided with the COVID-19 pandemic, a period of heightened hygiene awareness, the acceptability observed could differ in nonpandemic periods. Culturally adapted education, community engagement and reinforcement of correct use may enhance acceptability and sustainability in similar settings.

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HumansUgandaFemaleInfant, NewbornRural PopulationAdultHand DisinfectionQualitative ResearchMaleYoung AdultAnti-Infective Agents, LocalMothersInterviews as TopicFamily CharacteristicsPatient Acceptance of Health CareEthanolAcceptabilityhand hygieneinfection prevention and controlnewborn healthJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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Heidi H Thorsdalen, Ingunn Marie S Engebretsen, David Mukunya, Vivian Mutaki, Agnes Napyo, Thorkild Tylleskär, Andrew Weeks, Melf-Jakob Kühl. 2026-09-04. Acceptability of alcohol-based hand rub during neonatal care in rural Ugandan households: a qualitative study nested within the BabyGel trial.. https://doi.org/10.1080/16549716.2026.2727791

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Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't resourceAcceptability subjectAdult subjectAnti-Infective Agents, Local subjectEthanol subjectFamily Characteristics subjectFemale subjectHand Disinfection subjectHand hygiene subjectHumans subjectInfant, Newborn subjectInfection prevention and control subjectInterviews as Topic subjectJournal Article subjectMale subjectMothers subject

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