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Comparison of a 755-nm picosecond laser and a 1565-nm nonablative fractional laser for the treatment of atrophic acne scars: a 20-week prospective, randomized, split-face clinical study.

Junfeng Qi·Xinying Li·Xia Shu·Bingni Zhou·Zhouna Li
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Abstract

To compare the efficacy and safety of a 755-nm picosecond laser with a diffractive lens array (P-DLA) and a 1565-nm nonablative fractional laser (NAFL) for the treatment of atrophic acne scars. Twenty-seven patients with atrophic acne scars underwent three sessions of randomized split-face treatment with P-DLA and NAFL at 4-week intervals. Patients were followed up at 1, 2, and 3 months after the final treatment. Efficacy was assessed using the &#xc9;chelle d'&#xc9;valuation Clinique des Cicatrices d'Acn&#xe9; (ECCA) grading scale, the Investigator's Global Assessment (IGA) score, patients' self-rated improvement, and overall satisfaction. Treatment-related adverse reactions were recorded daily by patients until resolution. Both modalities demonstrated significant improvements in scar appearance based on ECCA score, IGA score, and patients' self-rated improvement (P&#x2009;<&#x2009;0.001). No statistically significant differences in efficacy were observed between the two treatments. However, the P-DLA group showed higher patient satisfaction (P&#x2009;=&#x2009;0.035) and a more favorable safety profile, including shorter durations of erythema and edema and the absence of crusting. Both P-DLA and NAFL were effective and safe for the treatment of atrophic acne scars, with similar efficacy. P-DLA offered better tolerability.

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HumansCicatrixFemaleAcne VulgarisAdultProspective StudiesPatient SatisfactionMaleLasers, Solid-StateYoung AdultTreatment OutcomeLow-Level Light TherapyAtrophyAdolescentAtrophic acne scarFractional laserLaser treatmentPicosecond laserJournal ArticleRandomized Controlled TrialComparative Study

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Junfeng Qi, Xinying Li, Xia Shu, Bingni Zhou, Zhouna Li. 2026-09-02. Comparison of a 755-nm picosecond laser and a 1565-nm nonablative fractional laser for the treatment of atrophic acne scars: a 20-week prospective, randomized, split-face clinical study.. https://doi.org/10.1007/s10103-026-05015-y

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Journal Article; Randomized Controlled Trial; Comparative Study resourceAdolescent subjectAdult subjectComparative Study subjectFemale subjectHumans subjectJournal Article subjectLow-Level Light Therapy subjectMale subjectPatient Satisfaction subjectRandomized controlled trials study

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