Functional Prediction of Epitranscriptome.

Yuxin Zhang; Bowen Song; Kunqi Chen

doi:10.1007/978-1-0716-5284-8_4

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Functional Prediction of Epitranscriptome.

Yuxin Zhang·Bowen Song·Kunqi Chen

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Abstract

N6-methyladenosine (m6A) is one of the most prevalent and well-studied RNA modifications, playing a pivotal role in many biological processes. With the recent advances in high-throughput sequencing technologies, tens of thousands of m6A sites have been reported. However, not all m6A sites are important or functionally significant, highlighting the need to distinguish biologically relevant m6As from non-functional or technically artefactual ones. Here, we describe ConsRM, which is a web-based resource that was designed to evaluate the importance of m6As from an evolutionary perspective. It introduced a novel scoring framework for quantifying the conservation degree of m6As in humans. Its web interface includes a database of 177998 distinct human m6A sites along with their calculated conservation score, and allows users to analyze their own data via the web server. ConsRM is freely accessible at: http://180.208.58.19/conservation/browser.html .

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Humans RNA Methylation Epitranscriptome Adenosine Computational Biology Software Epitranscriptomics Web Browser High-Throughput Nucleotide Sequencing Internet RNA Conservation analysis Evolutionary Genome analysis Machine learning N6-methyladenosine (m6A)Scoring framework Journal Article

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Yuxin Zhang, Bowen Song, Kunqi Chen. 2026. Functional Prediction of Epitranscriptome.. https://doi.org/10.1007/978-1-0716-5284-8_4

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