Applications of metal-organic frameworks in smart packaging for food freshness indication: a comprehensive review.

Shiliang Jia; Mingcheng Zhang; Xi Hao; Xirong Liu; Xia Xu; Shulai Liu; Yuting Ding; Yanbo Wang; Xuxia Zhou

doi:10.1016/j.foodres.2026.119941

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Applications of metal-organic frameworks in smart packaging for food freshness indication: a comprehensive review.

Shiliang Jia·Mingcheng Zhang·Xi Hao·Xirong Liu·Xia Xu·Shulai Liu·Yuting Ding·Yanbo Wang·Xuxia Zhou

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Abstract

Smart packaging is extensively studied for its multifunctional capabilities in antimicrobial activity, preservation, and atmosphere modification. Recently emerged metal-organic frameworks (MOFs) freshness-indicating packaging becomes a key research direction in smart packaging owing to its distinctive functions and physicochemical properties. As multifunctional materials, the unique porous structure and tunable properties of MOFs provide a distinctive approach for developing food packaging applications dedicated to food freshness indication. Existing MOFs-based smart packaging still faces potential safety risks and technical challenges in practical applications, and there remains a lack of integrated discussion that combines synthesis strategies, packaging design, optimization, and safety assessment. This review elaborates on the application of MOFs in freshness-indicating smart packaging, focusing on diverse MOFs synthesis strategies, the formats of smart packaging, types of indicator signals, and qualitative/quantitative analytical methods. It also delves into the methodology concepts of MOFs-based smart packaging and evaluates MOFs safety in food packaging by addressing potential risks. Studies show that MOFs-based smart packaging achieves qualitative and semi-quantitative analysis of food freshness through multiple signal modalities such as visible color change, fluorescence, and photothermal effects. This review emphasizes that safe MOFs design is critically important and should comply with the overall migration limit of <10 mg/dm2 specified in Regulation (EC) No 1935/2004, lanthanide element limit of <0.05 mg/kg, and FDA threshold of 1.5 μg/person/day. Comprehensive safety assessment and intelligent sensing platforms will constitute pivotal directions for advancing MOFs-based smart packaging toward practical application.

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Food Packaging Metal-Organic Frameworks Food Preservation Food Safety Humans Artificial intelligence Freshness detection Metal-organic frameworks Migration concentration limit Smart packaging Journal Article Review

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Shiliang Jia, Mingcheng Zhang, Xi Hao, Xirong Liu, Xia Xu, Shulai Liu, Yuting Ding, Yanbo Wang, Xuxia Zhou. 2026-07-11. Applications of metal-organic frameworks in smart packaging for food freshness indication: a comprehensive review.. https://doi.org/10.1016/j.foodres.2026.119941

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