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PubMed · 42678936

The 100 Diatom Genomes Project.

Thomas Mock·Gust Bilcke·Eliott Flaum·Shunan Fu·Lilian Hoch·Kevin Moog·Nadine Rijsdijk·Elizabeth C Ruck·Ian W Bishop·Carole Duchene·Reuben Gilbertson·Amanda Hopes·Christopher Johns·Francesco Manfellotto·Wade R Roberts·Nigel Belshaw·Udita Chandola·Peter Chaerle·Olga Chepurnova·Daan Deleu·Sofie D'hondt·Federica Di Costanzo·Omaya Dudin·Serena Flori·Trupti Gaikwad·Agnes Groisillier·Andrea Hall·Pengyu Ji·Louis J Lavier-Aydat·William H Lewis·Samuel Menicot·Eveline Pinseel·Eléonore Pottier·Krisztina Sarkozi·Arianna Smerilli·Jan Strauss·Sander Thierens·Andrew Toseland·Yousef Touhami·Robert Utting·Michiel Van Bel·Cock van Oosterhout·Yue Wu·Feng Yang·Erika Allhusen·John J Bolton·Chris Bowler·Thorsten Brinkhoff·Anja Poehlein·Tim Brovarone·Nansheng Chen·Greg Clark·Matthew D Clark·Dario Copetti·Zongmei Cui·Beini Deng·Jianbo Jian·Uwe John·Anne D Jungblut·JiHeon Kang·Jon Bent Kristoffersen·JunMo Lee·Shuya Liu·David G Mann·Linda Medlin·Vincent Moulton·Jelena Radojicic·Shinya Sato·Rosa Trobajo·Klara Wolf·Norico Yamada·Naihao Ye·Libin Zhang·Yunyun Zhuang·Gautam Dey·Valeria Di Dato·Katherine Helliwell·Marianne Jaubert·Peter G Kroth·Marina Montresor·Giovanna Romano·Tatiana A Rynearson·Jayson Talag·Klaus U Valentin·Flora Vincent·Ross F Waller·Glen Wheeler·Andrew J Alverson·Kerrie Barry·LoriBeth Boston·Angela Falciatore·Maria Immacolata Ferrante·Jie Guo·Jane Grimwood·Richard Hayes·Andrei Herdean·Jerry Jenkins·Min Kim·Wiebe Hcf Kooistra·Alan Kuo
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Abstract

One hundred diatom species have been selected for genome and transcriptome sequencing. The 100 Diatom Genomes Project aims to provide a scalable framework for understanding diatom biodiversity, ecology and evolution, and for investigating their use in biotechnology.

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DiatomsGenomeBiodiversityTranscriptomeGenomicsPhylogenyJournal Article

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Thomas Mock, Gust Bilcke, Eliott Flaum, Shunan Fu, Lilian Hoch, Kevin Moog, Nadine Rijsdijk, Elizabeth C Ruck, Ian W Bishop, Carole Duchene, Reuben Gilbertson, Amanda Hopes, Christopher Johns, Francesco Manfellotto, Wade R Roberts, Nigel Belshaw, Udita Chandola, Peter Chaerle, Olga Chepurnova, Daan Deleu, Sofie D'hondt, Federica Di Costanzo, Omaya Dudin, Serena Flori, Trupti Gaikwad, Agnes Groisillier, Andrea Hall, Pengyu Ji, Louis J Lavier-Aydat, William H Lewis, Samuel Menicot, Eveline Pinseel, Eléonore Pottier, Krisztina Sarkozi, Arianna Smerilli, Jan Strauss, Sander Thierens, Andrew Toseland, Yousef Touhami, Robert Utting, Michiel Van Bel, Cock van Oosterhout, Yue Wu, Feng Yang, Erika Allhusen, John J Bolton, Chris Bowler, Thorsten Brinkhoff, Anja Poehlein, Tim Brovarone, Nansheng Chen, Greg Clark, Matthew D Clark, Dario Copetti, Zongmei Cui, Beini Deng, Jianbo Jian, Uwe John, Anne D Jungblut, JiHeon Kang, Jon Bent Kristoffersen, JunMo Lee, Shuya Liu, David G Mann, Linda Medlin, Vincent Moulton, Jelena Radojicic, Shinya Sato, Rosa Trobajo, Klara Wolf, Norico Yamada, Naihao Ye, Libin Zhang, Yunyun Zhuang, Gautam Dey, Valeria Di Dato, Katherine Helliwell, Marianne Jaubert, Peter G Kroth, Marina Montresor, Giovanna Romano, Tatiana A Rynearson, Jayson Talag, Klaus U Valentin, Flora Vincent, Ross F Waller, Glen Wheeler, Andrew J Alverson, Kerrie Barry, LoriBeth Boston, Angela Falciatore, Maria Immacolata Ferrante, Jie Guo, Jane Grimwood, Richard Hayes, Andrei Herdean, Jerry Jenkins, Min Kim, Wiebe Hcf Kooistra, Alan Kuo. 2026-09-01. The 100 Diatom Genomes Project.. https://doi.org/10.1371/journal.pbio.3003947

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Diatoms are among the most ecologically successful microalgae, contributing significantly to marine primary production and global carbon cycling. Their distinctive metabolic architecture, shaped by a complex evolutionary history involving secondary endosymbiosis, includes a highly compartmentalized cell organization and unique metabolic pathways. In Phaeodactylum tricornutum, a model pennate diatom, chloroplasts with four membranes and mitochondria of likely exosymbiotic origin exhibit intricate physical and metabolic interactions that support integrated carbon and nitrogen metabolism. The mitochondrial electron transport chain, essential for ATP synthesis, shows clade-specific structural and compositional adaptations. Despite its importance, detailed proteomic characterization has remained limited. Here, we report a method for the isolation of mitochondrial complex I from P. tricornutum and present a comprehensive proteomic analysis. Our results confirm the presence of carbonic anhydrase and bridge modules, both previously proposed as ancestral features of mitochondrial complex I, and identify at least one novel, clade-specific subunit that resembles NAD(P)H-dependent trans-2-enoyl-CoA/ACP reductases (TER) from other species. The subunit is similar to proteins involved in mitochondrial fatty acid biosynthesis. Our findings provide new insights into the composition, evolutionary conservation, and potential biotechnological relevance of this essential respiratory protein complex in diatoms.

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