Symptom Burden After Dialysis Initiation and Its Association With Hospitalization.

Devika Nair; Xuan Cai; Ron D Hays; Olalekan L Aiyegbusi; Rebecca S Frazier; Tamara Isakova; John D Peipert

doi:10.1016/j.xkme.2026.101450

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Symptom Burden After Dialysis Initiation and Its Association With Hospitalization.

Devika Nair·Xuan Cai·Ron D Hays·Olalekan L Aiyegbusi·Rebecca S Frazier·Tamara Isakova·John D Peipert

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Abstract

RATIONALE & OBJECTIVE: Symptom burden is distressing for patients living with kidney failure, but there is limited information about the combination of symptoms and individual symptoms that most strongly predict health care use in this group. We classified and summarized patients' symptom burden levels and changes over time and estimated associations with hospitalizations among patients receiving incident hemodialysis. STUDY DESIGN: Longitudinal, observational. SETTING & PARTICIPANTS: Individuals initiating dialysis in the United States. EXPOSURE: Kidney Disease Quality of Life-36 (KDQOL-36) measure. OUTCOME: First hospitalization after dialysis initiation. ANALYTICAL APPROACH: Latent transition analysis was used to identify symptom burden classes using the KDQOL-36. Cox regression models were used to assess whether individual KDQOL-36 symptoms and symptom burden groups were associated with hospitalization risk after dialysis initiation, independent of demographics and comorbid conditions. RESULTS: 1,818 participants were Black (29%), were aged >65 years (59%), were women (42%), had diabetes (49%), and had hypertension (74%). Latent transition analysis identified the following 3 symptom burden groups: (1) low (low severity of all symptoms and kidney disease impacts), (2) moderate (high physical health impact and overall burden of kidney disease), and (3) high (high levels of all symptoms and kidney disease impact). After adjusting for patient characteristics, all KDQOL-36 scales except the Effects of Kidney Disease scale were associated with a higher hazard of hospitalization. Using the symptom burden groups, a high symptom burden was associated with a 20% increase in the hazard of hospitalization. A 1-category worsening in pain interference and in fatigue was associated with a 12% and an 8% increased hazard of hospitalization, respectively. LIMITATIONS: Findings may not generalize outside the United States. CONCLUSIONS: Pain interference and fatigue, as well as an overall symptom burden, are useful prognostic indicators in patients receiving in-center hemodialysis. Symptom burden should remain a treatment target in hemodialysis.

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Devika Nair, Xuan Cai, Ron D Hays, Olalekan L Aiyegbusi, Rebecca S Frazier, Tamara Isakova, John D Peipert. 2026-06-23. Symptom Burden After Dialysis Initiation and Its Association With Hospitalization.. https://doi.org/10.1016/j.xkme.2026.101450

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