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Trans-omics integration underscores distinct roles of polyunsaturated phospholipids in bidirectional offspring birth weight deviations.

Jia Zheng·Sin Man Lam·Wei Ling Florence Lim·Shixuan Zhang·Lili Mao·Qian Zhang·Jingkang Cui·Junqing Zhang·Ying Gao·Yurong Zhao·Guanghou Shui·Xinhua Xiao
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Abstract

BACKGROUND: Abnormal birth weights are associated with adverse pregnancy outcomes and future metabolic consequences. We aimed to examine cord blood lipidomes from low, normal and high birth weight (LBW, NBW, HBW) infants to identify core lipid signatures associated with non-optimum birth weight, and to derive biological insights through trans-omics data integration with placental proteome, maternal plasma lipidome and clinical phenome. METHODS: We conducted quantitative lipidomics of cord blood samples from two independent cohorts: a retrospective discovery cohort (n = 147) and a prospective validation cohort (n = 73). Integration with placental proteomics, maternal plasma lipidomics and clinical phenomics was conducted to elucidate potential biological implications. FINDINGS: We identified substantial reductions in cord blood polyunsaturated phospholipids (PUFA-PLs) (FDR <0.05) associated with placental vesicle trafficking and formation in LBW, and altered neutrophil degranulation in HBW. Combinatorial analyses of paired maternal plasma and cord blood samples indicated that cord blood PUFA-PL reductions were not attributable to deficient maternal supply, but rather to impeded assimilation (LBW) and increased utilisation (HBW). INTERPRETATION: Our findings provide biological insights that may inform targetable, lipid-oriented nutritional and/or pharmacological strategies to modulate foetal growth and development, with the goal of optimising clinical outcomes for both mother and child. FUNDING: This work was supported by the National Natural Science Foundation of China (82170854, 81870579, 81870545, 82571043, 2357308); National High Level Hospital Clinical Research Funding (2022-PUMCH-C-019); Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0530200 and 2024ZD0530204); Beijing Municipal Science & Technology Commission (Z201100005520011); Peking University Clinical Scientist Training Program (No. BMU2023PYJH022); Beijing Municipal Natural Science Foundation (7202163, 7184252).

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HumansFemaleBirth WeightPregnancyPhospholipidsFetal BloodInfant, NewbornLipidomicsMultiomicsFatty Acids, UnsaturatedPlacentaProteomicsAdultProteomeAbnormal birth weightCord blood lipidomicsPUFAsPlacental proteomicsJournal Article

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Jia Zheng, Sin Man Lam, Wei Ling Florence Lim, Shixuan Zhang, Lili Mao, Qian Zhang, Jingkang Cui, Junqing Zhang, Ying Gao, Yurong Zhao, Guanghou Shui, Xinhua Xiao. 2026-08-18. Trans-omics integration underscores distinct roles of polyunsaturated phospholipids in bidirectional offspring birth weight deviations.. https://doi.org/10.1016/j.ebiom.2026.106435

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