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Symptoms and treatment response to florensocatib and inhaled tobramycin in bronchiectasis: Post hoc analysis of two randomized trials.

Yong-Hua Gao·Xue-Shan Li·Xiao-Li Sun·Fang-Qiong Li·Lu-Yin Sun·Han-Mo Liu·Wei-Jie Guan
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Abstract

Inhaled antibiotics and DPP-1 inhibitors improve clinical outcomes in bronchiectasis, but whether baseline symptom burden predicts differential treatment responses remains unclear. In this post hoc analysis of two multicenter randomized trials (SAVE-BE, n = 224; TORNASOL, n = 357), we evaluate the association between baseline Quality of Life-Bronchiectasis Respiratory Symptom Scale (QoL-B-RSS) and treatment effects of florensocatib and inhaled tobramycin. In SAVE-BE, florensocatib reduces exacerbation rates versus placebo (relative risk [RR], 0.47; 95% confidence interval [CI], 0.33-0.67; p < 0.0001), with RRs of 0.53 and 0.40 observed in patients with high and low symptom burdens, respectively, but no significant symptomatic improvement. In TORNASOL, tobramycin produces clinically meaningful QoL-B-RSS improvements (exceeding the 8-point cutoff in high-symptom patients) and ameliorates bronchitic symptoms, with greater benefits in those with higher baseline symptom burden. These hypothesis-generating findings suggest that baseline symptom burden may identify differential responses to anti-inflammatory versus anti-infective therapies in bronchiectasis and support its potential as a simple, practical stratification tool to guide personalized treatment.

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HumansBronchiectasisTobramycinAdministration, InhalationQuality of LifeFemaleTreatment OutcomeAnti-Bacterial AgentsMaleMiddle AgedAgedSymptom BurdenDPP-1 inhibitorbronchiectasisexacerbationsinhaled tobramycinsymptomstreatment responseJournal ArticleRandomized Controlled Trial

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Yong-Hua Gao, Xue-Shan Li, Xiao-Li Sun, Fang-Qiong Li, Lu-Yin Sun, Han-Mo Liu, Wei-Jie Guan. 2026-08-13. Symptoms and treatment response to florensocatib and inhaled tobramycin in bronchiectasis: Post hoc analysis of two randomized trials.. https://doi.org/10.1016/j.xcrm.2026.102995

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Journal Article; Randomized Controlled Trial resourceAged subjectAnti-Bacterial Agents subjectFemale subjectHumans subjectJournal Article subjectMale subjectMiddle Aged subjectRandomized controlled trials study

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