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Memantine Augmentation for Obsessive-Compulsive Symptoms in Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.

Hamzeh Rostami·Zahra Dorafshan·Neda Sadrizadeh Irani·Sedighe Mofradnejad·Shahin Norouzi
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Abstract

BACKGROUND: Obsessive-compulsive symptoms are frequently observed in patients with bipolar disorder and present a significant therapeutic challenge. This study evaluated the efficacy and safety of memantine as an adjunctive therapy for obsessive-compulsive disorder in patients with bipolar disorder. METHODS: In this randomized, double-blind, placebo-controlled trial, 46 patients with bipolar disorder and obsessive-compulsive disorder, stabilized on quetiapine and lithium, were randomly assigned to receive either memantine (n = 23) or placebo (n = 23) for 6 weeks. RESULTS: The memantine group showed a significant reduction in Yale-Brown Obsessive-Compulsive Scale scores compared with the placebo group (Cohen d = 1.57 vs 0.42, P < 0.001). Nausea was the most common side effect, but overall adverse effects were minimal. CONCLUSION: Memantine appears to be a safe and effective adjunctive treatment for obsessive-compulsive disorder in patients with bipolar disorder, warranting further investigation.

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HumansBipolar DisorderDouble-Blind MethodObsessive-Compulsive DisorderMemantineFemaleMaleAdultDrug Therapy, CombinationMiddle AgedTreatment OutcomeQuetiapine FumarateAntimanic AgentsAntipsychotic Agentsadjunctive therapybipolar disordermemantineobsessive-compulsive symptomsrandomized controlled trialJournal ArticleRandomized Controlled Trial

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Hamzeh Rostami, Zahra Dorafshan, Neda Sadrizadeh Irani, Sedighe Mofradnejad, Shahin Norouzi. 2026-08-13. Memantine Augmentation for Obsessive-Compulsive Symptoms in Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.. https://doi.org/10.1097/jcp.0000000000002188

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Journal Article; Randomized Controlled Trial resourceAdult subjectAntimanic Agents subjectAntipsychotic Agents subjectBipolar Disorder subjectDouble-Blind Method subjectDrug Therapy, Combination subjectFemale subjectHumans subjectJournal Article subjectMale subjectMemantine subjectMiddle Aged subjectObsessive-Compulsive Disorder subjectRandomized controlled trials study

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