Pharmacogenomic and drug interactions risk in cardio-oncology: A precision medicine perspective for India.

Aanya Verma; Priya D

doi:10.1016/j.cpcardiol.2026.103422

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Pharmacogenomic and drug interactions risk in cardio-oncology: A precision medicine perspective for India.

Aanya Verma·Priya D

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Abstract

Cardio-oncology patients may face complex treatment regimens due to the concurrent existence of cancer and cardiovascular disease, leading to a considerable polypharmacy burden. This significantly increases the prospect of drug-drug interactions (DDIs) and gene-drug interactions. The majority of these interactions arise from comparable pharmacokinetic and pharmacological pathways associated with drug transporters and cytochrome P450 enzymes. The significance of pharmacogenomics in tailored treatment strategies are emphasised by the fact that genetic variability enhances individual differences in drug response, safety, and efficacy. This narrative review focus on the effects of key genetic polymorphisms (e.g., DPYD, CYP2C19, and CYP2C9) on the metabolism and efficacy of commonly prescribed anticancer and cardiovascular medications such as fluoropyrimidines, clopidogrel, and warfarin. In addition it explore the role of pharmacogenomic variants on drug-drug interactions within the field of cardio-oncology. The study ultimately emphasizes the necessity of precision medicine in India to address the genetic diversity and underrepresentation in global genomic databases. The absence of pharmacogenomic testing, infrastructural deficiencies, financial constraints, and insufficient clinical integration hinder the widespread use of this technology in India. The Genome India Project and other national initiatives establish the foundation for pharmacogenomic-guided therapy. Utilizing genetic data, together with artificial intelligence-based predictive tools, for clinical decision-making may enhance medication safety and yield optimal outcomes in Indian cardio-oncology patients.

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Humans Precision Medicine Drug Interactions Pharmacogenetics Neoplasms Cardiovascular Diseases India Antineoplastic Agents Polymorphism, Genetic Cardiovascular Agents AI integration Drug metabolism Drug-drug interactions Pharmacogenomics Precision medicine Journal Article Review

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Aanya Verma, Priya D. 2026-08-12. Pharmacogenomic and drug interactions risk in cardio-oncology: A precision medicine perspective for India.. https://doi.org/10.1016/j.cpcardiol.2026.103422

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Journal Article; Review resource Antineoplastic Agents subject Cardiovascular Diseases subject Humans subject India subject Journal Article subject Neoplasms subject Pharmacogenetics subject

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