Efficacy of targeted neuromodulation treatments: a clinical report.

Stephen Erle; Nina Hashimoto; Andrew Lang; Alaa Abd-Elsayed

doi:10.1080/17434440.2026.2709771

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Efficacy of targeted neuromodulation treatments: a clinical report.

Stephen Erle·Nina Hashimoto·Andrew Lang·Alaa Abd-Elsayed

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Abstract

BACKGROUND: Peripheral neuropathy is a debilitating condition characterized by chronic pain, numbness, tingling, burning, and tightness/swelling. Conventional therapies often focus on symptom management, and some patients experience chronic and refractory symptoms. RESEARCH DESIGN AND METHODS: This retrospective clinical analysis evaluated the clinical outcomes of neuromodulation neuropathy treatment using the NeuroGen-Series device in patients with diabetic peripheral neuropathy (DPN) or idiopathic peripheral neuropathy (IPN). 9,805 unique patients who underwent 133,741 treatments between 18 August 2017, and 23 July 2024, were analyzed. Patients were divided into treatment completers (≥24 sessions) and noncompleters (<24 sessions). Paired t-tests confirmed statistically significant reductions in pre- and post-treatment symptom scores (p < 0.001). RESULTS: Among completers, symptom severity decreased by an average of 46.2%. Tingling and pain showed the greatest improvement, while tightness/swelling and numbness showed the least reduction. 64% of patients reported improvement after one session, and 84% reported improvement after 24 sessions. Nonresponders accounted for 5.8% of patients overall. Younger patients and those with higher initial symptom severity were more likely to discontinue treatment. CONCLUSIONS: Overall, neuromodulation treatment resulted in statistically significant reductions in symptom severity, though nonresponders and high attrition rate highlight the need for individualized treatment strategies and further investigation.

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Humans Female Treatment Outcome Male Middle Aged Diabetic Neuropathies Retrospective Studies Electric Stimulation Therapy Aged Peripheral Nervous System Diseases Peripheral neuropathy diabetic peripheral neuropathy frequency cell signaling therapy idiopathic peripheral neuropathy neuromodulation neuropathy treatment Journal Article

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Stephen Erle, Nina Hashimoto, Andrew Lang, Alaa Abd-Elsayed. 2026-07-30. Efficacy of targeted neuromodulation treatments: a clinical report.. https://doi.org/10.1080/17434440.2026.2709771

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