Association between pulse pressure and markers of cognitive function: a systematic review and meta-analysis.

Olivia Gaunt; Kaavya Venkatesh; Ryan McNally; Phil J Chowienczyk; Marina Cecelja

doi:10.1097/hjh.0000000000004401

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Association between pulse pressure and markers of cognitive function: a systematic review and meta-analysis.

Olivia Gaunt·Kaavya Venkatesh·Ryan McNally·Phil J Chowienczyk·Marina Cecelja

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Abstract

Our aim was to systematically review and meta-analyse evidence on the association between pulse pressure (PP) and cognitive function using PubMed, PsycInfo, Embase and Scopus (inception-July 2025) publication databases. Studies were included if they reported an association between PP and cognitive function and summarized narratively and by performing fixed-effects meta-analysis. The search identified 4171 publications with 43 studies meeting inclusion criteria. Domains assessed included global cognition, memory, language, attention, executive function, processing speed and visuospatial ability. Meta-analysis suggests a positive association between PP and global cognition, and a negative association with memory in both cross-sectional and longitudinal studies with inconsistent findings from narratively summarized studies. Processing speed, executive function and language negatively associated with PP in cross-sectional studies with limited evidence provided by longitudinal studies or narratively summarized studies. There was limited evidence of an association with attention and visuospatial ability.

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Olivia Gaunt, Kaavya Venkatesh, Ryan McNally, Phil J Chowienczyk, Marina Cecelja. 2026-07-24. Association between pulse pressure and markers of cognitive function: a systematic review and meta-analysis.. https://doi.org/10.1097/hjh.0000000000004401

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Attention subject Blood Pressure subject Cognition subject Executive Function subject Humans subject Journal Article subject Journal Article; Systematic Review; Meta-Analysis resource Meta-Analysis subject Systematic reviews study memory subject

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