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Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series.

Shoshana Greenberger·Efrat Bar-Ilan·Victoria Marcu·Evgeny Grishin·Rinat Yacobi·Aviv Barzilai·Hana Golan·Assaf Arie Barg
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Abstract

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30-positive T-cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin-limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel PICALM::JAK2 fusion not previously described in pcALCL. Clinical courses ranged from spontaneous regression to systemic therapy, yet all achieved durable complete remission without progression over 31-50 months. These findings highlight previously unrecognized genomic diversity and expand the molecular landscape of pediatric pcALCL.

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HumansMaleLymphoma, Primary Cutaneous Anaplastic Large CellFemaleChildSkin NeoplasmsChild, PreschoolPrognosisGenetic VariationAdolescentcutaneous lymphomamolecularpediatricJournal ArticleCase Reports

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BibTeXRIS

Shoshana Greenberger, Efrat Bar-Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg. 2026-07-21. Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series.. https://doi.org/10.1002/1545-5017.70437

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