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Risk factors for loss of skeletal muscle mass in patients with chronic kidney disease on a low-protein diet.

Satoko Notomi·Hideyuki Kabasawa·Toshiko Murayama·Mai Tanaka·Suguru Yamamoto·Michihiro Hosojima
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Abstract

OBJECTIVES: A low-protein diet (LPD) is recommended for patients with chronic kidney disease (CKD) to prevent a further decline in renal function. However, its impact on muscle mass in these patients remains unclear. This study investigated the risk factors for loss of muscle mass in patients with CKD on an LPD. METHODS: Eighty-four patients with predialysis CKD (59 men, mean age 61.9 &#xb1; 11.5 y) who participated in a multicenter randomized controlled trial initiated in 2014 were retrospectively reviewed. We collected data on baseline blood and urine tests, body composition, and dietary records at the start and end of the observation period. We evaluated muscle mass using the skeletal muscle index (SMI) and analyzed risk factors for a decrease in SMI during the 24-wk observation period, using logistic regression analysis. Variables with an association (P < 0.1) in univariate analysis, as well as age, sex, use of low-protein rice, and changes in protein intake, were subjected to multivariate analysis. RESULTS: SMI decreased in 50 patients (59.5%) during the observation period. Multivariate analysis identified significant associations of the SMI with serum albumin at baseline (odds ratio 0.11, 95% confidence interval 0.02-0.52, P = 0.004) and changes in energy intake while on the LPD (odds ratio 3.39, 95% confidence interval 1.00-11.43, P = 0.049). CONCLUSIONS: Risk factors for reduced SMI in patients with CKD on an LPD were malnutrition when initiating the LPD and reduced energy intake during its implementation. Clinicians should optimize nutritional status before initiation of an LPD and ensure adequate energy intake throughout treatment.

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HumansMaleFemaleRisk FactorsRenal Insufficiency, ChronicMiddle AgedDiet, Protein-RestrictedMuscle, SkeletalRetrospective StudiesAgedBody CompositionSarcopeniaLogistic ModelsSerum AlbuminDietary ProteinsChronic kidney diseaseEnergy and protein intakeLow-protein diet therapyMalnutritionSkeletal muscle massJournal ArticleMulticenter StudyRandomized Controlled Trial

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Satoko Notomi, Hideyuki Kabasawa, Toshiko Murayama, Mai Tanaka, Suguru Yamamoto, Michihiro Hosojima. 2026-06-26. Risk factors for loss of skeletal muscle mass in patients with chronic kidney disease on a low-protein diet.. https://doi.org/10.1016/j.nut.2026.113344

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Aged subjectBody Composition subjectChronic kidney disease subjectDietary Proteins subjectFemale subjectHumans subjectJournal Article subjectJournal Article; Multicenter Study; Randomized Controlled Trial resourceMale subjectMiddle Aged subjectMulticenter Study subjectMuscle, Skeletal subjectRandomized controlled trials study

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