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Clinical performance of two lithium disilicate CAD/CAM materials in posterior Class II inlay restorations: A 48-month randomised split-mouth clinical trial.

Seung-Kyung Kwon·Sangmin Song·Sera Jeon·Lisu Sung·Yooseok Shin·Dohyun Kim
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Abstract

OBJECTIVES: To compare the clinical performance of Amber Mill (AM) and IPS e.max CAD (EM) lithium disilicate computer-aided design/computer-aided manufacturing (CAD/CAM) materials in posterior Class II inlay restorations and characterise their baseline properties. METHODS: Thirty-four adults received paired AM and EM posterior Class II inlays (68 restorations) in a triple-blind randomised split-mouth trial followed for 48 months. Restorations were evaluated at baseline and annually using revised World Dental Federation (FDI) criteria, with fracture and retention as the primary endpoint. Baseline characterisation included flexural strength, shear bond strength, translucency parameter, and scanning electron microscopy. McNemar, Wilcoxon signed-rank, Friedman, one-way analysis of variance, Tukey post hoc, and inter-rater agreement analyses were used. RESULTS: At 48 months, 18 paired participants were available for primary analysis. Failures occurred in 2 of 18 AM restorations and in 3 of 18 EM restorations, corresponding to success rates of 88.9% and 83.3%, respectively, with no significant between-material difference (McNemar p = 1.000). No catastrophic bulk ceramic fracture was observed. Secondary FDI scores remained mostly within the clinically acceptable range; marginal staining deteriorated over time in both groups (p < .001) without significant between-material differences. Baseline material testing showed significant material- and translucency-dependent differences in flexural strength, shear bond strength, and translucency. CONCLUSIONS: Within the limitations of the 48-month follow-up and the tested Class II inlay indication, AM showed clinical performance comparable to EM. Observed clinical complications were related to retention or marginal/interface behaviour. CLINICAL SIGNIFICANCE: For posterior Class II lithium disilicate CAD/CAM inlays, medium-term complications were mainly retention/interface-related, suggesting adhesive-interface durability may be as important as baseline ceramic strength.

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HumansDental PorcelainComputer-Aided DesignInlaysShear StrengthDental Restoration FailureFlexural StrengthDental BondingFemaleAdultMaleMiddle AgedSurface PropertiesMicroscopy, Electron, ScanningFollow-Up StudiesMaterials TestingDental MaterialsCAD/CAMFDI criteriaInlayLithium disilicateRandomised controlled trialSplit-mouthJournal ArticleRandomized Controlled TrialComparative Study

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Seung-Kyung Kwon, Sangmin Song, Sera Jeon, Lisu Sung, Yooseok Shin, Dohyun Kim. 2026-07-10. Clinical performance of two lithium disilicate CAD/CAM materials in posterior Class II inlay restorations: A 48-month randomised split-mouth clinical trial.. https://doi.org/10.1016/j.jdent.2026.106895

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Journal Article; Randomized Controlled Trial; Comparative Study resourceAdult subjectCAD/CAM subjectComparative Study subjectComputer-Aided Design subjectDental Bonding subjectDental Materials subjectDental Porcelain subjectDental Restoration Failure subjectFDI criteria subjectFemale subjectFlexural Strength subjectFollow-Up Studies subjectHumans subjectInlay subjectInlays subject

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