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Disparities in guideline-adherent cardiovascular preventive care for people with diabetes: A systematic review and meta-analysis.

Katharine Mackett·Diana Sherifali·Russell J de Souza·Manchit Singh Kalra·Samuel Ramos-Acevedo·Reese Cameron·Nancy A Santesso
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Abstract

BACKGROUND: Clinical practice guidelines offer guidance on delaying the progression of cardiovascular disease in people living with diabetes. We sought to determine whether guideline-recommended cardiovascular preventive care for people living with diabetes differs according to sociodemographic indicators, globally. METHODS: We conducted a systematic review of studies that compared the sociodemographic characteristics of people diagnosed with type 1 or 2 diabetes who received cardiovascular preventive care as recommended by guidelines to those who did not. Sociodemographic predictors were defined by PROGRESS+ (an equity framework). We searched MEDLINE, EMBASE, and APA PsychInfo from 2010 to January 21, 2026. Studies were screened independently by two people. One person assessed the risk of bias and extracted data, and another verified. We pooled results using a random-effects model and assessed the certainty of evidence using GRADE. RESULTS: Twenty-five studies were included. Meta-analyses showed female, Black, and Hispanic individuals had slightly lower odds of receiving guideline-recommended prescriptions for lipid-lowering medication compared to Male, and White individuals, respectively (OR:0.89, 95%CI:0.79,1.00, moderate certainty; OR:0.78, 95%CI:0.74,0.81, high certainty; OR:0.86, 95%CI:0.59,1.26, low certainty). Individuals aged 18-45 years had moderately lower odds (OR:0.33, 95%CI:0.19,0.57, moderate certainty), no observed association for Asian individuals. Asian individuals had moderately lower odds of antihypertensive medication prescription (OR:0.42, 95%CI:0.38,0.46, high certainty). Evidence suggests likely no association between HbA1c testing and sex/gender or between sex/gender and lipid panel testing. CONCLUSIONS: Some disparities in guideline-recommended cardiovascular preventive care among people living with diabetes were found. These results are consistent with previous reviews and highlight the need to ensure guidelines consider equity and with improved dissemination.

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HumansHealthcare DisparitiesGuideline AdherenceCardiovascular DiseasesPractice Guidelines as TopicFemaleMaleDiabetes Mellitus, Type 2Middle AgedAdultDiabetes Mellitus, Type 1AgedUndertreatmentTreatment OutcomeRisk FactorsPractice Patterns, Physicians'EpidemiologyHealth Equity and DisparitiesMeta-AnalysisPreventive CardiologyJournal ArticleSystematic ReviewReview

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Katharine Mackett, Diana Sherifali, Russell J de Souza, Manchit Singh Kalra, Samuel Ramos-Acevedo, Reese Cameron, Nancy A Santesso. 2026-07-08. Disparities in guideline-adherent cardiovascular preventive care for people with diabetes: A systematic review and meta-analysis.. https://doi.org/10.1016/j.pcd.2026.07.003

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Adult subjectAged subjectCardiovascular Diseases subjectDiabetes Mellitus, Type 2 subjectEpidemiology subjectFemale subjectHumans subjectJournal Article subjectJournal Article; Systematic Review; Meta-Analysis; Review resourceMale subjectMeta-Analysis subjectMiddle Aged subjectSystematic reviews study

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