Retinoid dynamics in immune cells during age-related diseases.

Yunge Wang; Atikah Tsabita Muslihah; Mengwei Fu; Xuan Dong; Ying Fu

doi:10.1016/j.cytogfr.2026.07.001

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Retinoid dynamics in immune cells during age-related diseases.

Yunge Wang·Atikah Tsabita Muslihah·Mengwei Fu·Xuan Dong·Ying Fu

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Abstract

Retinoids comprise vitamin A and its structurally related natural and synthetic derivatives. Retinoid dynamics involves multiple retinoid forms, carrier proteins, and enzymes that orchestrate the absorption, transport, storage and biotransformation of dietary vitamin A. Beyond their canonical metabolic functions, metabolites and proteins involved in retinoid metabolism also play distinct roles in signal transduction and transcriptome reprogramming, broadening the mechanisms that influence immune cell fate decisions. Age‑related changes in retinoid bioavailability and signaling intensity alter immune cell polarization and function, thereby contributing to the pathogenesis of chronic inflammation in neurodegenerative diseases, cardiovascular diseases, osteoarthritis, and other age-related diseases. In this review, we focus on age-related alterations in the retinoid metabolic pathway and their impact on inflammation and the progression of age-related diseases. This review highlights the pivotal role of retinoid metabolism in anti-ageing interventions and considers future directions and challenges in this field.

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Humans Retinoids Aging Animals Inflammation Signal Transduction Cardiovascular Diseases Neurodegenerative Diseases Age-related disease Chronic inflammation Immune cells Retinoid metabolism Journal Article Review

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Yunge Wang, Atikah Tsabita Muslihah, Mengwei Fu, Xuan Dong, Ying Fu. 2026-07-05. Retinoid dynamics in immune cells during age-related diseases.. https://doi.org/10.1016/j.cytogfr.2026.07.001

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Journal Article; Review resource Aging subject Animals subject Cardiovascular Diseases subject Humans subject Journal Article subject Neurodegenerative Diseases subject inflammation subject

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