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Postoperative complications and outcomes after surgical treatment for tophaceous gout: A systematic review and meta-analysis.

Rong-Zhen Xie·Xu-Song Li·Wen-Rui Wu·Wei-Qiang Zhao·Yu-Feng Liang·Jie-Feng Huang·You-Xin Su
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Abstract

BACKGROUND: Surgical treatment remains necessary for selected patients with tophaceous gout, particularly when mechanical limitation, nerve compression, ulceration, infection, deformity, or failure of conservative treatment is present. However, postoperative outcomes after surgery for tophaceous gout have not been comprehensively quantified. This systematic review and meta-analysis evaluated postoperative complication profiles and recurrence burden after surgical treatment for tophaceous gout. METHODS: A systematic search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted from database inception to March 25, 2026. Original studies reporting postoperative outcomes after surgical treatment for tophaceous gout were included. Pooled event rates with 95% confidence intervals (CIs) were calculated using a random-effects single-arm meta-analytic approach. Primary outcomes were postoperative infection, delayed wound healing, and recurrence. Secondary outcomes were reoperation, amputation, and overall complications. Functional outcomes were summarized descriptively. RESULTS: 18 retrospective studies were included. The pooled postoperative infection rate was 11.3% (95% CI 8.0%-15.7%), delayed wound healing 9.9% (95% CI 5.1%-18.2%), and recurrence 8.5% (95% CI 4.7%-14.9%). Secondary pooled rates were 9.7% (95% CI 5.5%-16.7%) for reoperation, 3.7% (95% CI 2.0%-6.8%) for amputation, and 24.0% (95% CI 14.0%-38.1%) for overall complications. Significant subgroup differences were identified only for infection according to anatomic site and intervention type. Sensitivity analyses showed that pooled estimates were robust. The certainty of evidence was very low for all outcomes. CONCLUSIONS: Surgical treatment for tophaceous gout is associated with measurable postoperative risks, particularly infection and overall complications. These findings support careful perioperative counseling, structured postoperative surveillance, integrated long-term urate-lowering management, and more standardized reporting of perioperative risk factors and postoperative outcomes in future surgical studies of tophaceous gout.

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HumansPostoperative ComplicationsGoutTreatment OutcomeRecurrenceMeta-analysisPostoperative outcomesSurgical treatmentSystematic reviewTophaceous goutJournal ArticleSystematic ReviewMeta-AnalysisReview

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Rong-Zhen Xie, Xu-Song Li, Wen-Rui Wu, Wei-Qiang Zhao, Yu-Feng Liang, Jie-Feng Huang, You-Xin Su. 2026-06-30. Postoperative complications and outcomes after surgical treatment for tophaceous gout: A systematic review and meta-analysis.. https://doi.org/10.1016/j.semarthrit.2026.153038

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Humans subjectJournal Article subjectJournal Article; Systematic Review; Meta-Analysis; Review resourceMeta-Analysis subjectPostoperative Complications subjectSystematic reviews study

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