Pancreatic Cancer: Translating Tumor Biology into Actionability.

Fiyinfolu O Balogun; Mara H Sherman; Wungki Park; Kevin C Soares; Marsha Reyngold; Joshua D Schoenfeld; Anupriya Singhal; Christine A Iacobuzio-Donahue; Eileen M O'Reilly

doi:10.1158/2159-8290.cd-25-2014

PubMed · 42381464

Pancreatic Cancer: Translating Tumor Biology into Actionability.

Fiyinfolu O Balogun·Mara H Sherman·Wungki Park·Kevin C Soares·Marsha Reyngold·Joshua D Schoenfeld·Anupriya Singhal·Christine A Iacobuzio-Donahue·Eileen M O'Reilly

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Abstract

UNLABELLED: Pancreatic ductal adenocarcinoma (PDAC) accounts for 90% of pancreatic cancers and has a very poor prognosis. Ten to 15% are staged as resectable at diagnosis, and 5% to 15% downstaged with therapy to where surgery is feasible. Chemotherapy is a mainstay for all stages of PDAC. Targeted therapies are available for patients with select but expanding actionable genomic alterations. The tumor microenvironment provides a dense stroma with an immunosuppressive milieu that contributes to inherent treatment resistance of PDAC. Herein, we review current management of PDAC with a focus on emerging treatment paradigms, including targeted and immunomodulatory agents. SIGNIFICANCE: PDAC is a complex disease with unique genomic, immunologic, and clinical features. Recent developments in understanding of the pathobiology of this disease are translating into targeted and immunomodulatory therapies that will alter treatment paradigms and improve outcomes for this recalcitrant malignancy.

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Humans Pancreatic Neoplasms Carcinoma, Pancreatic Ductal Tumor Microenvironment Molecular Targeted Therapy Animals Journal Article Review

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Fiyinfolu O Balogun, Mara H Sherman, Wungki Park, Kevin C Soares, Marsha Reyngold, Joshua D Schoenfeld, Anupriya Singhal, Christine A Iacobuzio-Donahue, Eileen M O'Reilly. 2026-07-01. Pancreatic Cancer: Translating Tumor Biology into Actionability.. https://doi.org/10.1158/2159-8290.cd-25-2014

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