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Liver transcriptome analysis revealed multiple immune processes and lipid metabolism pathways involved in the defense response of the turbot (Scophthalmus maximus) against Aeromonas salmonicida.

Wenqi Ren·Dong Sheng·Yuxiao Liu·Xu Ren·Xiaolong Ding·Ying Wang·Qinghua Yu·Weijia Zhou·Shigen Ye·Zhixin Guo
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Abstract

Aeromonas salmonicida is a significant pathogen causing notable economic losses in Scophthalmus maximus aquaculture. This study utilized Illumina sequencing technology to examine the transcriptional response characteristics of S. maximus liver at 24 h following A. salmonicida infection. A total of 2363 differentially expressed genes (DEGs) were identified when compared to the negative control group. The immunity-related Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, as well as metabolism-related PPAR signaling pathway and insulin signaling pathway, were notably enriched. Significant differences exist in the expression of key genes within the PPAR pathway, particularly cd36, acsl4a, pparαa, and plin2, all of which mediate the interaction between lipid metabolism and the immune response. These results offer valuable insights into the immunometabolic regulatory mechanism of S. maximus response to A. salmonicida infection.

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AnimalsAeromonas salmonicidaFlatfishesLipid MetabolismFish DiseasesLiverGram-Negative Bacterial InfectionsGene Expression ProfilingTranscriptomeFish ProteinsSignal TransductionImmunityMetabolismScophthalmus maximusTranscriptome analysisJournal Article

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Wenqi Ren, Dong Sheng, Yuxiao Liu, Xu Ren, Xiaolong Ding, Ying Wang, Qinghua Yu, Weijia Zhou, Shigen Ye, Zhixin Guo. 2026-06-12. Liver transcriptome analysis revealed multiple immune processes and lipid metabolism pathways involved in the defense response of the turbot (Scophthalmus maximus) against Aeromonas salmonicida.. https://doi.org/10.1016/j.cbd.2026.101901

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Journal Article resourceAnimals subjectFish Diseases subjectFish Proteins subjectFlatfishes subjectGene Expression Profiling subjectJournal Article subjectLipid Metabolism subjectLiver subject

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