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Dengue and chikungunya vaccines past, present and future: implications for travelers.

Francesca F Norman·Sarah L McGuinness·Lin H Chen
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Abstract

PURPOSE OF REVIEW: Novel vaccines for dengue and chikungunya viruses offer new prevention options against two globally important arboviral diseases. This review summarizes recent developments in vaccine licensure, implementation, real-world experience and research priorities, with emphasis on implications for both endemic populations and travelers. RECENT FINDINGS: Of the three live-attenuated dengue vaccines licensed to date, TAK-003 is authorized in >40 countries and Butantan-DV in Brazil, while manufacturing of CYD-TDV is discontinued. Long-term and postmarketing data continue to refine understanding of serotype-specific protection, waning immunity, and rare adverse events.For chikungunya, two single-dose vaccines are licensed-a live-attenuated vaccine (VLA1553) and virus-like particle vaccine (PXVX0317). Uptake is guided by emerging safety and effectiveness data, with each platform offering potential advantages in different settings.Further data on long-term protection, safety, effectiveness, use in vulnerable populations and integration into outbreak management and immunization systems is anticipated. SUMMARY: Dengue and chikungunya vaccines are increasingly being used in immunization programs and pretravel consultations. Further real-world data are needed-particularly for seronegative dengue vaccine recipients and older, immunocompromised or medically at-risk adults. Research priorities include developing single-dose, nonlive dengue vaccines suitable for high-risk groups, understanding long-term chikungunya vaccine performance, and exploring broader flaviviral or pan-arboviral platforms.

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HumansDengue VaccinesChikungunya FeverDengueTravelVaccines, AttenuatedChikungunya virusDengue VirusViral VaccinesVaccine DevelopmentVFR (Visiting Friends and Relatives)arboviruschikungunyadengueimmunizationinternationalmigrantpreventionJournal ArticleReview

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Francesca F Norman, Sarah L McGuinness, Lin H Chen. 2026-06-10. Dengue and chikungunya vaccines past, present and future: implications for travelers.. https://doi.org/10.1097/qco.0000000000001211

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