Multi-omic biomarkers in cardiovascular disease: Discovery to clinical translation.

Tareq Nayef AlRamadneh; Waleed K Abdulsahib; Tushar B Gajjar; Malathi Hanumanthayya; Sandeep Kumar Shukla; Rajashree Panigrahi; Neeraj Bainsal; Jasur Rizaev; Bobur Abduvoyitov; Djamila Polatova

doi:10.1016/j.cca.2026.121182

PubMed · 42288272

Multi-omic biomarkers in cardiovascular disease: Discovery to clinical translation.

Tareq Nayef AlRamadneh·Waleed K Abdulsahib·Tushar B Gajjar·Malathi Hanumanthayya·Sandeep Kumar Shukla·Rajashree Panigrahi·Neeraj Bainsal·Jasur Rizaev·Bobur Abduvoyitov·Djamila Polatova

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Abstract

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, necessitating improved risk stratification and early detection strategies. Multiomics approaches that integrate genomics, transcriptomics, proteomics, metabolomics, and epigenomics offer unprecedented opportunities for biomarker discovery and precision medicine in cardiovascular care. This narrative review examines the current landscape of multiomics biomarkers for CVD, tracing their evolution from discovery to clinical translation. We synthesize evidence from recent studies evaluating the clinical utility of integrated omics approaches across diverse cardiovascular conditions, including atherosclerotic cardiovascular disease, heart failure, and atrial fibrillation. High-throughput proteomics has identified novel protein signatures that enhance cardiovascular risk prediction beyond traditional risk factors. Metabolomics has revealed pathway-specific biomarkers, including trimethylamine N-oxide and lipid species, associated with atherogenesis. Polygenic risk scores derived from genomic data demonstrate incremental value when combined with clinical risk scores. Multiomics biomarkers represent a transformative approach to cardiovascular risk assessment and disease management.

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Humans Cardiovascular Diseases Biomarkers Multiomics Translational Research, Biomedical Metabolomics Proteomics Cardiovascular disease Precision medicine Journal Article Review

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Tareq Nayef AlRamadneh, Waleed K Abdulsahib, Tushar B Gajjar, Malathi Hanumanthayya, Sandeep Kumar Shukla, Rajashree Panigrahi, Neeraj Bainsal, Jasur Rizaev, Bobur Abduvoyitov, Djamila Polatova. 2026-06-13. Multi-omic biomarkers in cardiovascular disease: Discovery to clinical translation.. https://doi.org/10.1016/j.cca.2026.121182

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Journal Article; Review resource Biomarkers subject Cardiovascular Diseases subject Cardiovascular disease subject Humans subject Journal Article subject Metabolomics subject Multiomics subject

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