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Effect of Perioperative Sucralfate Administration on Pain Control After Tonsillectomy: A Systemic Review and Meta-Analysis.

Do Hyun Kim·David W Jang·Se Hwan Hwang
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Abstract

OBJECTIVES: This study evaluated the efficacy of perioperative intraoral sucralfate in reducing postoperative pain following tonsillectomy through a systematic review and meta-analysis. METHODS: A comprehensive search of PubMed, SCOPUS, Embase, Web of Science, and Cochrane up to September 2025 identified 13 studies comparing perioperative intraoral sucralfate with placebo or no treatment. Outcomes included throat pain, otalgia, swallowing pain, analgesic consumption, and perioperative morbidities. RESULTS: Sucralfate increased the proportion of patients reporting no or mild throat pain and otalgia, improved mucosal healing at 5 to 7 days, and reduced throat pain, swallowing pain, otalgia, analgesic use, and time to resume >50% of a regular diet. No significant differences were observed in postoperative bleeding or nausea/vomiting. CONCLUSION: Perioperative intraoral sucralfate may be an effective adjuvant therapy that improves postoperative pain control, enhances wound healing, reduces analgesic requirements, and facilitates earlier dietary resumption after tonsillectomy.

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HumansSucralfateTonsillectomyPostoperative PainAnti-Ulcer AgentsPain ManagementAnalgesicsPerioperative CareWound Healingmeta-analysispainsucralfatetonsillectomytreatment outcomeJournal ArticleSystematic ReviewMeta-Analysis

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Do Hyun Kim, David W Jang, Se Hwan Hwang. 2026-05-13. Effect of Perioperative Sucralfate Administration on Pain Control After Tonsillectomy: A Systemic Review and Meta-Analysis.. https://doi.org/10.1177/00034894261449776

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Analgesics subjectAnti-Ulcer Agents subjectHumans subjectJournal Article subjectJournal Article; Systematic Review; Meta-Analysis resourceMeta-Analysis subjectPain subjectPain Management subjectPerioperative Care subjectPostoperative Pain subjectSystematic reviews study

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