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Mitomycin C in the Endoscopic Treatment of Airway Stenosis: A Systematic Review and a Meta-Analysis.

Elena Russo·Giuseppe Mangiameli·Andrea Costantino·Umberto Cariboni·Bianca Maria Festa·Marco Alloisio·Giuseppe Spriano·Giuseppe Marulli·Giorgio Maria Ferraroli·Armando De Virgilio
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Abstract

OBJECTIVE: To assess the efficacy of adjuvant MMC in the endoscopic treatment of airway stenoses. DATA SOURCES: PubMed/MEDLINE, Cochrane Library, Scopus, Embase, and Google Scholar databases. REVIEW METHODS: A literature search was conducted following PRISMA guidelines. The PICOS tool was used to determine the eligibility criteria for this study. A single arm meta-analysis was performed for stenosis resolution, the rate of patients requiring multiple endoscopic procedures, and the rate of patients requiring other surgical treatments. RESULTS: A total number of 358 patients (median age: 48.0 years; 95% CI 44.8-50.8) were included. The median follow-up was 25.2 months (n = 244/358; 95% CI 15.4-38.3). Overall, the cumulative stenosis resolution rate was 76.37% (n = 187/254; 95% CI 59.72-89.64), the rate of patients requiring multiple endoscopic procedures was 52.33% (n = 131/260; 95% CI 32.03-72.25), and the rate of patients requiring other surgical treatments was 4.08% (n = 26/310; 95% CI 0.37-11.48). The median intervention-free interval was 366 days (n = 155/358; 95% CI 270-696). CONCLUSIONS: Current evidence does not allow definitive conclusions regarding the efficacy of adjuvant MMC in reducing recurrence or prolonging intervention-free intervals in airway stenosis. Further well-designed prospective studies are needed to clarify the role of MMC and to inform evidence-based guidelines for patient selection and treatment use. LEVEL OF EVIDENCE: NA.

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HumansTracheal StenosisMitomycinLaryngostenosisEndoscopyTreatment OutcomeAlkylating Agentsairway stenosisendoscopic treatmentlaryngotracheal stenosismitomycin Csubglottic stenosistracheal stenosisJournal ArticleSystematic ReviewMeta-Analysis

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Elena Russo, Giuseppe Mangiameli, Andrea Costantino, Umberto Cariboni, Bianca Maria Festa, Marco Alloisio, Giuseppe Spriano, Giuseppe Marulli, Giorgio Maria Ferraroli, Armando De Virgilio. 2026-05-13. Mitomycin C in the Endoscopic Treatment of Airway Stenosis: A Systematic Review and a Meta-Analysis.. https://doi.org/10.1177/00034894261449765

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Humans subjectJournal Article subjectJournal Article; Systematic Review; Meta-Analysis resourceMeta-Analysis subjectSystematic reviews study

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