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Postoperative chemoradiotherapy in Wilms tumor with concurrent lung and lymph node metastasis.

Kongfeng Shao·Xijin Lin·Zhuhong Chen·Haojie Zhu
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Abstract

BACKGROUND: An effective treatment strategy is essential for metastatic Wilms tumor (WT) management. To improve prognostic accuracy, this study examined metastatic patterns and key prognostic factors. METHODS: Children diagnosed with WT from 2010 to 2021 were identified from the SEER database. All patients underwent chemotherapy and surgical resection. Metastatic patterns, metastasis-related predictors, and prognostic factors were evaluated. RESULTS: Of the 1040 patients analyzed, 226 (21.7%) experienced lung metastasis, 31 (3.0%) liver metastasis, 6 (0.6%) bone metastasis, and 220 (21.2%) regional lymph node metastasis. Distant metastasis was associated with a higher incidence of lymph node metastasis (OR = 1.506, 95% CI 1.346-1.685, p < 0.001). Age 3-17 years (OR = 1.933, 95% CI 1.406-2.680, p < 0.001), left-sided (OR = 1.383, 95% CI 1.016-1.890, p = 0.040), bilateral (OR = 2.303, 95% CI 1.215-4.243, p = 0.009), and tumor size &#x2265;135 mm (OR = 2.020, 95% CI 1.481-2.749, p < 0.001) were identified as predictors of metastasis. Both lymph node (p < 0.001) and lung metastasis (p < 0.001) were high-risk factors for WT. Radiotherapy provided long-term survival benefits for the metastatic population (p = 0.027), while postoperative chemotherapy showed better outcomes than preoperative or other strategies (p < 0.001). Further analysis demonstrated that the concurrent lung and lymph node metastasis group benefited more from postoperative chemoradiotherapy, with HRs of 0.226 (p = 0.028) for overall survival and 0.255 (p = 0.048) for cancer-specific survival. CONCLUSION: WT with concurrent lung and lymph node metastasis represents a distinct and aggressive metastatic phenotype associated with a significantly poor prognosis. Postoperative chemoradiotherapy may provide superior survival benefits for this high-risk population.

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HumansWilms TumorLymphatic MetastasisFemaleKidney NeoplasmsChild, PreschoolLung NeoplasmsChildMaleAdolescentPrognosisSEER ProgramRetrospective StudiesChemoradiotherapyNephrectomyMetastatic patternsPredictorsSEERWilms tumorJournal Article

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Kongfeng Shao, Xijin Lin, Zhuhong Chen, Haojie Zhu. 2026-04-21. Postoperative chemoradiotherapy in Wilms tumor with concurrent lung and lymph node metastasis.. https://doi.org/10.1016/j.jpurol.2026.105977

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Journal Article resourceAdolescent subjectChild subjectChild, Preschool subjectFemale subjectHumans subjectJournal Article subjectLung Neoplasms subjectMale subject

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