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Bacterial Lysates Add-On Therapy to Reduce Postoperative Recurrence in Nasal Polyps.

Huiyi Deng·Huijun Qiu·Tian Yuan·Shuo Wu·Qintai Yang
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Abstract

OBJECTIVE: This study aimed to investigate the potential role of OM-85 in reducing polyp recurrence (PR). METHODS: A single-center randomized, prospective study was performed to compare the inter-group PR rate, patient-reported outcome measures (PROMs), CT and endoscopic scores. Hundred patients were randomized to receive either add-on OM-85 (34/50) or control group (43/50); 77 participants completed the 12-month follow-up. The OM-85 group received oral treatment for 10&#x2009;days, followed by a 20-day washout (Months 1-3 and 7-9). Primary outcome was the PR rate. Secondary outcomes included PROMs, Lund-Kennedy (L-K) scores, Lund-Mackay (L-M) scores, and complete blood count (CBC) parameters. RESULTS: The PR rate was significantly lower in the OM-85 group (8.82%) than in the control group (27.91%, &#x3c7; 2&#x2009;=&#x2009;4.408, p&#x2009;=&#x2009;0.036). Univariable analysis identified pre-operative Lund-Mackay (L-M) score (p&#x2009;=&#x2009;0.008) and hyposmia VAS score (p&#x2009;=&#x2009;0.031) as significant predictors of PR. In multivariable analysis, the L-M score remained an independent predictor (OR&#x2009;=&#x2009;1.15, p&#x2009;=&#x2009;0.012), with an optimal cutoff of 10. The OM-85 group showed significant improvements in nasal obstruction, olfactory dysfunction, and mucopurulent discharge at 6 and 12&#x2009;months (p&#x2009;<&#x2009;0.05). Lund-Kennedy (L-K) score and 22-item Sinonasal Outcome Test (SNOT-22) score were also significantly improved (p&#x2009;<&#x2009;0.05). Furthermore, the OM-85 group exhibited elevated white blood cell counts and lymphocyte percentages from 6&#x2009;months onward (p&#x2009;<&#x2009;0.05). CONCLUSION: Adjuvant OM-85 may reduce postoperative PR, with improved endoscopic and symptom scores, potentially mediated by enhanced systemic immune function.

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HumansFemaleMaleProspective StudiesNasal PolypsBacterial LysatesMiddle AgedTreatment OutcomeCell ExtractsAdultSecondary PreventionRecurrenceEndoscopyFollow-Up Studiesbacterial lysatesimmune responsenasal polypsolfactory dysfunctionrecurrenceJournal ArticleRandomized Controlled Trial

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Huiyi Deng, Huijun Qiu, Tian Yuan, Shuo Wu, Qintai Yang. 2026-04-27. Bacterial Lysates Add-On Therapy to Reduce Postoperative Recurrence in Nasal Polyps.. https://doi.org/10.1002/lary.70581

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Journal Article; Randomized Controlled Trial resourceAdult subjectFemale subjectFollow-Up Studies subjectHumans subjectImmune response subjectJournal Article subjectMale subjectMiddle Aged subjectRandomized controlled trials study

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