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PubMed · 42009205

Linked-color imaging with computer-aided detection and the proximal adenoma miss rate: a randomized tandem trial.

Naohiko Akimoto·Osamu Goto·Takayoshi Nishimoto·Tsugumi Habu·Ryosuke Inoue·Shun Nakagome·Yuka Shimazu·Aitoshi Hoshimoto·Eriko Koizumi·Kazutoshi Higuchi·Jun Omori·Ryuji Ohashi·Atsushi Tatsuguchi·Katsuhiko Iwakiri
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Abstract

BACKGROUND AND AIMS: Linked-color imaging (LCI) aids the detection and characterization of lesions. Computer-aided detection (CADe) systems have been introduced to improve lesion detection during colonoscopy. Although several studies have been reported regarding LCI, few have investigated the combination of LCI and CADe. This study aimed to evaluate the efficacy of LCI with CADe colonoscopy compared to conventional white-light colonoscopy. METHODS: A single-center, randomized tandem trial was conducted. Participants referred for first-time colonoscopy after fecal immunochemical test (FIT)-positive, asymptomatic screening, or surveillance colonoscopy were randomized (1:1) to undergo CADe-assisted colonoscopy of LCI or white-light imaging (WLI) in the right side of the colon. The primary outcome was adenoma miss rate (AMR) in the right side of the colon. Secondary outcomes included polyp miss rate (PMR), diminutive adenoma miss rate (dAMR), sessile serrated lesion miss rate (SSLMR), advanced adenoma miss rate, advanced neoplasia miss rate, flat-type lesion miss rate (FMR), and the differences in miss rates based on expertise. RESULTS: Among 232 randomized participants, 209 were analyzed (LCI/CADe: 102; WLI: 107). AMR (WLI: 39% vs LCI/CADe: 20%; P = .001), PMR (42% vs 18%; P < .001), and dAMR (42% vs 21%; P = .003) were significantly lower in the LCI/CADe arm, particularly among experts. SSLMR (46% vs 0%), advanced AMR (30% vs 0%), advanced neoplasia miss rate (25% vs 0%), and FMR (27% vs 5.6%) were lower in LCI/CADe, although without statistical significance. CONCLUSIONS: Compared to conventional colonoscopy, LCI with CADe colonoscopy resulted in a statistically significant decrease, especially in AMR. (UMIN 000050685).

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HumansColonoscopyAdenomaFemaleMaleMiddle AgedColonic PolypsAgedColorectal NeoplasmsMissed DiagnosisDiagnosis, Computer-AssistedJournal ArticleRandomized Controlled Trial

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Naohiko Akimoto, Osamu Goto, Takayoshi Nishimoto, Tsugumi Habu, Ryosuke Inoue, Shun Nakagome, Yuka Shimazu, Aitoshi Hoshimoto, Eriko Koizumi, Kazutoshi Higuchi, Jun Omori, Ryuji Ohashi, Atsushi Tatsuguchi, Katsuhiko Iwakiri. 2026-04-18. Linked-color imaging with computer-aided detection and the proximal adenoma miss rate: a randomized tandem trial.. https://doi.org/10.1016/j.gie.2026.04.014

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Journal Article; Randomized Controlled Trial resourceAged subjectColorectal Neoplasms subjectDiagnosis, Computer-Assisted subjectFemale subjectHumans subjectJournal Article subjectMale subjectMiddle Aged subjectRandomized controlled trials study

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