Congenital Laryngomalacia: Pathophysiology, Clinical Spectrum, and Holistic Management.

Inbal Hazkani; Taher Valika; Dana Mara Thompson

doi:10.1016/j.otc.2026.03.008

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Congenital Laryngomalacia: Pathophysiology, Clinical Spectrum, and Holistic Management.

Inbal Hazkani·Taher Valika·Dana Mara Thompson

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Abstract

Congenital laryngomalacia is the most common cause of infant stridor and arises from interacting structural, neuromuscular, and inflammatory mechanisms that produce dynamic supraglottic collapse. Disease severity spans mild stridor to significant obstruction, aspiration, and failure to thrive, often influenced by comorbid medical conditions. Diagnosis relies on flexible laryngoscopy supported by instrumental swallowing studies and microdirect laryngoscopy and bronchoscopy when indicated. Most infants respond to conservative management, particularly targeted feeding modifications, while acid suppression offers benefit in selective cases. Supraglottoplasty provides effective, durable improvement for severe disease and significantly enhances infant outcomes and family quality of life.

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Humans Laryngomalacia Laryngoscopy Respiratory Sounds Infant Infant, Newborn Bronchoscopy Deglutition Disorders Quality of Life Congenital Abnormalities Larynx Aerodigestive disorders Aspiration Dysphagia Infant stridor Supraglottic collapse Supraglottoplasty Journal Article Review

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Inbal Hazkani, Taher Valika, Dana Mara Thompson. 2026-04-09. Congenital Laryngomalacia: Pathophysiology, Clinical Spectrum, and Holistic Management.. https://doi.org/10.1016/j.otc.2026.03.008

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Journal Article; Review resource Humans subject Infant subject Infant, Newborn subject Journal Article subject dysphagia subject

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