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Effects of Sacubitril Valsartan Combined With Vericiguat on NT-proBNP and CK-MB Levels in Patients With Chronic Heart Failure.

Lijuan Jin·Tingting Yang
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Abstract

This study aims to probe the influence of sacubitril valsartan sodium tablets combined with vericiguat on N-terminal pro-B-type natriuretic peptide (NT-proBNP) and creatine kinase isoenzyme (CK-MB) levels in patients with chronic heart failure (CHF). One hundred and twenty CHF patients were enrolled and stratified into a control group (sacubitril valsartan sodium tablets) and a combination group (sacubitril valsartan sodium tablets + vericiguat). Outcome measures included New York Heart Association (NYHA) functional class shifts, echocardiographic indices, cardiac injury markers, 6-min walk distance (6MWD), endothelial function parameters, inflammatory mediator levels, and adverse clinical events. Following a 6-month treatment period, patients in the combination group exhibited superior functional improvement, as reflected by greater advancement in NYHA class. Echocardiographic evaluation revealed more favorable ventricular remodeling in this group, with reduced left ventricular end-diastolic and end-systolic diameters and an elevated ejection fraction. The combination group had a higher 6MWD. Biomarker analysis showed lower NT-proBNP and CK-MB levels in the combination group. Furthermore, improvements in endothelial function were noted, with decreased endothelin and elevated NO, NOS, and CGRP levels in the combination group. Markers of systemic inflammation, including CRP and IL-6, were also attenuated in the combination group. The incidence of adverse reactions and cardiovascular events did not differ significantly between the groups. Co-administration of sacubitril/valsartan and vericiguat enhances cardiac performance, optimizes vascular endothelial responsiveness, modulates heart failure-related biomarkers, and mitigates inflammatory activity in patients with CHF without increasing the risk of adverse events.

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HumansHeart FailureNatriuretic Peptide, BrainPeptide FragmentsFemaleAminobutyratesMaleBiphenyl CompoundsDrug CombinationsCreatine Kinase, MB FormMiddle AgedValsartanChronic DiseaseBiomarkersTetrazolesAgedN‐terminal pro‐B‐type natriuretic peptidechronic heart failurecreatine kinase isoenzymeinflammatory factorsacubitril valsartan sodium tabletsvericiguatJournal ArticleRandomized Controlled Trial

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Lijuan Jin, Tingting Yang. 2026-04-09. Effects of Sacubitril Valsartan Combined With Vericiguat on NT-proBNP and CK-MB Levels in Patients With Chronic Heart Failure.. https://doi.org/10.1002/jat.70150

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Journal Article; Randomized Controlled Trial resourceAged subjectAminobutyrates subjectBiomarkers subjectBiphenyl Compounds subjectDrug Combinations subjectFemale subjectHeart Failure subjectHumans subjectJournal Article subjectMale subjectMiddle Aged subjectNatriuretic Peptide, Brain subjectPeptide Fragments subjectRandomized controlled trials study

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