Oxeiptosis - potential in cancer treatment?

Mateusz Kciuk; Katarzyna Wanke; &#x17b;aneta Ka&#x142;uzi&#x144;ska-Ko&#x142;at; Renata Kontek

doi:10.1017/erm.2026.10045

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Oxeiptosis - potential in cancer treatment?

Mateusz Kciuk·Katarzyna Wanke·Żaneta Kałuzińska-Kołat·Renata Kontek

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Abstract

Oxeiptosis is a reactive oxygen species (ROS)-dependent form of programmed cell death that plays a key role in cellular homeostasis and holds promise as a cancer therapy. This review explores its molecular mechanisms, emphasizing the KEAP1-PGAM5-AIFM1 signalling pathway and its reliance on ROS accumulation. Compared to other cell death pathways, oxeiptosis offers a distinct approach, especially for targeting cancer cells resistant to conventional therapies. The review evaluates emerging inducers, both synthetic and natural, that selectively trigger oxeiptosis in cancer cells. It also examines the potential synergy between oxeiptosis and ROS-generating chemotherapies, particularly in the oxidative tumour microenvironment. However, challenges remain, including identifying tumour-specific inducers, overcoming cancer cell resistance to oxidative stress and reducing off-target effects. The review concludes by highlighting the need for targeted delivery strategies and rigorous preclinical studies to translate oxeiptosis into effective cancer treatments. Overall, it underscores oxeiptosis as a promising avenue to address drug resistance and improve therapeutic outcomes in oncology.

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Humans Reactive Oxygen Species Neoplasms Oxidative Stress Animals Signal Transduction Antineoplastic Agents Apoptosis Tumor Microenvironment Drug Resistance, Neoplasm cell death chemotherapy oxeiptosis oxidative stress reactive oxygen species (ROS)Journal Article Review

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Mateusz Kciuk, Katarzyna Wanke, Żaneta Kałuzińska-Kołat, Renata Kontek. 2026-03-27. Oxeiptosis - potential in cancer treatment?. https://doi.org/10.1017/erm.2026.10045

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