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Risk of adverse events in elotuzumab-treated patients with multiple myeloma: a systematic review and meta-analysis.

Zhaoyue Yan·Huali Dong·Yiping Du·Dapeng Li·Linlin Liu
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Abstract

BACKGROUND: Elotuzumab, an anti-SLAMF7 monoclonal antibody for multiple myeloma (MM), lacks a comprehensive safety profile from meta-analysis. METHODS: We systematically searched PubMed, Web of Science, EMBASE and CENTRAL through February 13, 2025 for randomized controlled trials (RCTs) evaluating elotuzumab in MM. Pooled relative risks(RRs) of adverse events observed in elotuzumab-containing regimens versus control therapies. RESULTS: 6 RCTs (N=1,736) were included. Elotuzumabsignificantly reduced incidence of neutropenia (RR = 0.86, 95% CI: 0.76-0.98), but increased risks of cough (RR = 1.41, 95% CI: 0.96-2.09), pneumonia (RR = 1.30, 95% CI: 1.07-1.59), diarrhea (RR = 1.16, 95% CI: 1.05-1.30), pyrexia (RR = 1.47, 95% CI: 1.10-1.96) and infections (RR = 1.09, 95% CI: 1.03-1.15). No significant differences were observed for anemia, thrombocytopenia, respiratory infections, nausea, appetite loss, back pain, muscle spasms, peripheral edema, insomnia, rash, pruritus, fatigue, or hypokalemia. For grade 3-4 events, elotuzumab was associated with higher risks of lymphopenia (RR = 1.86, 95% CI: 1.31-2.64, p = 0.0005, I2 = 9%), diarrhea (RR = 1.47, 95% CI: 1.00-2.17), pneumonia (RR = 1.57, 95% CI: 1.11-2.23), cataracts (RR = 2.87, 95% CI: 1.15-7.21) and infections (RR = 1.30, 95% CI: 1.04-1.62). CONCLUSION: Elotuzumab in MM appears safe but with a specific adverse events pattern : lower neutropenia, but higher respiratory, gastrointestinal, metabolic, and infectious events. Differences may be influenced by longer treatment and corticosteroid use; therefore, interpretation of outcomes such as hyperglycemia and cataracts requires particular caution.

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HumansMultiple MyelomaAntibodies, Monoclonal, HumanizedRandomized Controlled Trials as TopicNeutropeniaDiarrheaAntineoplastic Agents, ImmunologicalCoughPneumoniaMultiple myelomaadverse eventselotuzumabmeta-analysisJournal ArticleSystematic ReviewMeta-AnalysisResearch Support, Non-U.S. Gov't

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Zhaoyue Yan, Huali Dong, Yiping Du, Dapeng Li, Linlin Liu. 2026-03-12. Risk of adverse events in elotuzumab-treated patients with multiple myeloma: a systematic review and meta-analysis.. https://doi.org/10.1080/07853890.2026.2641930

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Antibodies, Monoclonal, Humanized subjectCough subjectDiarrhea subjectHumans subjectJournal Article subjectJournal Article; Systematic Review; Meta-Analysis; Research Support, Non-U.S. Gov't resourceMeta-Analysis subjectSystematic reviews study

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