Unravelling Ovarian Cancer: an analysis of the Influence of LRP1 and PAI1 Genetic Variations.

R B Devi Krishna; Sneha Grace Mathews; Preet Agarwal; C Elizabeth Rani; Nandini Krishnamurthy; Sanjana Murali; A Lohitha Rani; Leena Dennis Joseph; Banukeerthana Rajasekaran; F Andrea Mary

doi:10.1007/s10528-026-11331-3

PubMed · 41729408

Unravelling Ovarian Cancer: an analysis of the Influence of LRP1 and PAI1 Genetic Variations.

R B Devi Krishna·Sneha Grace Mathews·Preet Agarwal·C Elizabeth Rani·Nandini Krishnamurthy·Sanjana Murali·A Lohitha Rani·Leena Dennis Joseph·Banukeerthana Rajasekaran·F Andrea Mary

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Abstract

To assess the potential association between LRP1 (rs715948) and PAI1 (rs2227631, rs1799889) gene variation and ovarian cancer (OC) susceptibility. This study evaluated the genotypic and allelic distributions of LRP1 gene and PAI1 gene variants using Restriction Fragment Length Polymorphism (RFLP) analysis in 134 °C patients and 134 healthy controls. LRP1 (rs715948) showed a significant association with OC risk. The TC genotype was (OR = 3.7823, 95% CI: 2.1732-6.5825, p < 0.0001), and the CC genotype has (OR = 2.1613, 95% CI: 1.0054-4.6459, p = 0.0484). The C allele was significantly more frequent in cases (46%) than controls (32%) (OR = 1.7684, 95% CI: 1.2443-2.5133, p = 0.0015). For PAI1 (rs2227631), AG and GG genotypes showed no significant association (p = 0.3519 and p = 0.1165, respectively). PAI1 (rs1799889) AG genotype was (OR = 5.855, 95% CI: 2.4663-13.9027, p < 0.0001), while GG genotype showed no significance (p = 0.1025). The dominant model of LRP1, (TC + CC) and C alleles, were significantly more frequent in OC cases, indicating a potential risk factor. In contrast, the dominant models (AG + GG) and G alleles of PAI1 (rs2227631, rs1799889) showed no significance with OC susceptibility. Genetic variation in LRP1 (rs715948) significantly associated with increased OC risk, particularly the TC and CC genotypes and C allele. The C allele of this gene is key markers linked to higher OC susceptibility. Whereas in PAI1 (rs2227631, rs1799889), dominant models (AG + GG) show no significance, association suggesting a less prominent role in OC susceptibility. These findings highlight LRP1 as a potential genetic biomarker for OC risk assessment, while the role of PAI1 variants warrants further investigation in larger sample size.

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Humans Female Ovarian Neoplasms Low Density Lipoprotein Receptor-Related Protein-1 Plasminogen Activator Inhibitor 1 Genetic Predisposition to Disease Polymorphism, Single Nucleotide Middle Aged Case-Control Studies Alleles Genotype Adult Gene variation LRP1 Ovarian cancer PAI1 RFLP Journal Article

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R B Devi Krishna, Sneha Grace Mathews, Preet Agarwal, C Elizabeth Rani, Nandini Krishnamurthy, Sanjana Murali, A Lohitha Rani, Leena Dennis Joseph, Banukeerthana Rajasekaran, F Andrea Mary. 2026-02-23. Unravelling Ovarian Cancer: an analysis of the Influence of LRP1 and PAI1 Genetic Variations.. https://doi.org/10.1007/s10528-026-11331-3

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Journal Article resource Adult subject Alleles subject Case-Control Studies subject Female subject Genetic Predisposition to Disease subject Genotype subject Humans subject Journal Article subject Middle Aged subject Ovarian Neoplasms subject Plasminogen Activator Inhibitor 1 subject Polymorphism, Single Nucleotide subject

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