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Pediatric intracranial inflammatory myofibroblastic tumor harboring DCTN1::ALK fusion: a case report with radiologic-pathologic-molecular correlation.

Ali Jama Ali·Qiang Li·Chengyuan Dong
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Abstract

Central nervous system inflammatory myofibroblastic tumors are rare; pediatric DCTN1::ALK fusion cases are exceptionally uncommon. Here, we present an eight-year-old boy who presented with headache, vomiting, and a rapidly enlarging right frontal scalp mass. An MRI showed a dural, extra-axial lesion with mass effect. Histology confirmed IMT, and ALK immunohistochemistry was positive; next-generation sequencing (NGS) identified DCTN1 (exon 1-27)-ALK (exon 20-29) fusion, and FISH confirmed ALK rearrangement (33/100 nuclei). Genomic metrics showed tumor mutational burden (TMB) of 0.94/Mb, microsatellite stability, and CNV burden of 2.1%. He underwent near total resection followed by alectinib; to our knowledge, this is the first reported young pediatric (<10&#xa0;years old) CNS IMT with this fusion.

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HumansMaleChildAnaplastic Lymphoma KinaseDynactin ComplexNeoplasms, Muscle TissueBrain NeoplasmsMagnetic Resonance ImagingCentral nervous systemDCTN1::ALKGene fusionInflammatory myofibroblastic tumorPediatricJournal ArticleCase ReportsResearch Support, Non-U.S. Gov't

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Ali Jama Ali, Qiang Li, Chengyuan Dong. 2026-01-16. Pediatric intracranial inflammatory myofibroblastic tumor harboring DCTN1::ALK fusion: a case report with radiologic-pathologic-molecular correlation.. https://doi.org/10.1007/s00381-026-07136-9

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