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The gut microbiota-obesity axis in the pathogenesis and prognosis of breast cancer.

Huiyue Zhang·Yue Wang·Benyi Ning·Yiwen Wang·Tao Sun·Junnan Xu
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Abstract

BACKGROUND: Breast cancer (BC) remains a major global health concern, accounting for 11.7% of all cancer cases and ranking as the second leading cause of female cancer-related deaths worldwide. Increasing evidence highlights the interplay between gut microbiota (GM) dysbiosis and obesity-associated metabolic dysfunction in BC progression. This review aims to elucidate the role of GM in obese patients with BC. METHODS: A systematic literature search was conducted in PubMed and Web of Science databases for publications from July 2015 to January 2025. Search terms combined BC, GM, obesity, dysbiosis, immunity, and microbiome. Article selection prioritized studies investigating microbial alterations in BC patients, mechanistic links between obesity and cancer progression, and GM-targeted interventions. Both original studies and authoritative reviews were included, supplemented by manual reference screening. DISCUSSION: Obesity may trigger systemic inflammation, altered adipokine secretion, and disrupted steroid hormone metabolism via gut-derived β-glucuronidase activity, thereby exacerbating BC occurrence and recurrence. GM dysbiosis-driven metabolites such as branched-chain amino acids (BCAAs) and short-chain fatty acids (SCFAs) can activate oncogenic signaling pathways and immunosuppressive myeloid-derived suppressor cells (MDSCs), fostering tumor immune evasion. Conversely, dietary interventions, probiotics, and fecal microbiota transplantation (FMT) can alleviate dysbiosis, strengthen gut barriers, and restore anti-tumor immunity, improving chemotherapy response and reducing recurrence. However, challenges persist in deciphering BC subtype-related microbial signatures and optimizing microbiota-targeted therapies. CONCLUSION: Future longitudinal studies are needed to clarify causal relationships, validate microbial biomarkers, and translate preclinical findings into clinical applications. Addressing the gut-breast axis may offer transformative potential for precision oncology in obesity-driven BC.

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HumansObesityBreast NeoplasmsGastrointestinal MicrobiomeFemaleDysbiosisPrognosisProbioticsBreast cancerdysbiosisgut microbiotaimmunityobesityprognosisJournal ArticleSystematic ReviewResearch Support, Non-U.S. Gov't

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Huiyue Zhang, Yue Wang, Benyi Ning, Yiwen Wang, Tao Sun, Junnan Xu. 2026-01-07. The gut microbiota-obesity axis in the pathogenesis and prognosis of breast cancer.. https://doi.org/10.1080/07853890.2025.2611203

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Breast Neoplasms subjectDysbiosis subjectFemale subjectGastrointestinal Microbiome subjectGut microbiota subjectHumans subjectJournal Article subjectJournal Article; Systematic Review; Research Support, Non-U.S. Gov't resourceObesity subjectSystematic reviews study

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