Association between anaemia and osteoporosis: a systematic review and meta-analysis.

Alveron Andreas Tear; Florencia Anastasia Tesno; Haneira Shofiadeita; Gading Marcell Bunga; Hamidah Nur Taqiya; Najwa Audrey Sanditha; Ayesha Humayra Fayyaza; Samantha Kerenhapukh Tiurlina Tambunan; Gisela Kayla Wangsa; Qanita Reezqi Fatimah; Istiqomah Istiqomah; Widya Wibawanty; Leonardo Lubis

doi:10.1080/07853890.2025.2610878

PubMed · 41496457

Association between anaemia and osteoporosis: a systematic review and meta-analysis.

Alveron Andreas Tear·Florencia Anastasia Tesno·Haneira Shofiadeita·Gading Marcell Bunga·Hamidah Nur Taqiya·Najwa Audrey Sanditha·Ayesha Humayra Fayyaza·Samantha Kerenhapukh Tiurlina Tambunan·Gisela Kayla Wangsa·Qanita Reezqi Fatimah·Istiqomah Istiqomah·Widya Wibawanty·Leonardo Lubis

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Abstract

BACKGROUND: Osteoporosis significantly impacts global morbidity. Recent evidence suggests anaemia may contribute to osteoporosis risk. This systematic review and meta-analysis investigates this association. METHODS: PubMed, Scopus, EBSCO, and ScienceDirect were searched for papers. Studies with definition of anaemia and assessing osteoporosis outcomes were included. Meta-analysis utilized random-effects models (DerSimonian-Laird method), and study quality was assessed via Newcastle-Ottawa Scale (NOS). Analyses were performed using R Studio. RESULT: Eighteen studies (861,540 participants) were analyzed. Anaemia significantly increased osteoporosis risk in univariate analysis (OR 1.62; 95% CI 1.33-1.98; p < 0.001), despite high heterogeneity (I2 = 92.7%). The results remain significant in studies that reported multivariate analysis (OR 2.01; 95% CI 1.26-3.21; p = 0.004). Sensitivity analyses confirmed the robustness of our result. CONCLUSION: Anaemia significantly associated with osteoporosis, emphasizing the need for targeted screening in anaemic individuals. Further studies should consider incorporating anaemia into osteoporosis and fracture prediction tools.

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Humans Anemia Osteoporosis Osteoporotic Fractures Risk Factors Anaemia haemoglobin osteoporosis risk factor Systematic Review Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

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Alveron Andreas Tear, Florencia Anastasia Tesno, Haneira Shofiadeita, Gading Marcell Bunga, Hamidah Nur Taqiya, Najwa Audrey Sanditha, Ayesha Humayra Fayyaza, Samantha Kerenhapukh Tiurlina Tambunan, Gisela Kayla Wangsa, Qanita Reezqi Fatimah, Istiqomah Istiqomah, Widya Wibawanty, Leonardo Lubis. 2026-01-06. Association between anaemia and osteoporosis: a systematic review and meta-analysis.. https://doi.org/10.1080/07853890.2025.2610878

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Anemia subject Humans subject Journal Article subject Meta-Analysis subject Osteoporotic Fractures subject Systematic Review; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't resource Systematic reviews study

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