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Education, socioeconomic status, leisure sedentary behaviors and female infertility: mendelian randomization study.

Yiyuan Qu·Xujia Huang·Jinqiao Mi·Xuzhi Chen·Bingbing Wu·Jian Xu
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Abstract

BACKGROUND: Previous studies have indicated that education, socioeconomic status, and leisure sedentary behavior may be associated with female infertility. However, it remains unclear whether these associations imply causal relationships. METHODS: Genetic variants from genome-wide association studies (GWAS) of education, socioeconomic status, and leisure sedentary behaviors were obtained from the UK Biobank and MRC-IEU database (Medical Research Council Integrative Epidemiology Unit), female infertility data was acquired from the FinnGen Biobank. Univariable and multivariable MR analyses were performed to explore the relationships between these traits and female infertility. RESULTS: The results of the univariate MR analysis indicated that age of full-time education had a protective effect on female infertility (odds ratio [OR] 0.471; 95% confidence interval [CI] 0.24 to 0.93; p = 0.03). Multivariable MR and reverse MR studies support the existence of a relationship between them. However, no causal correlation was found between other traits and female infertility. No significant heterogeneity or horizontal pleiotropy was detected, and the stability of the results was confirmed through sensitivity analysis and the leave-one-out test. CONCLUSIONS: A later age of completion of full-time education may be causally related to a reduced risk of female infertility, but no causality is established between other educational levels factors, socioeconomic status, or sedentary behaviors and infertility risk.

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HumansFemaleMendelian Randomization AnalysisSedentary BehaviorEducational StatusSocial ClassInfertility, FemaleLeisure ActivitiesGenome-Wide Association StudyAdultMiddle AgedUnited KingdomFull-time education level and infertilityInfertility riskMendelian randomizationJournal Article

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Yiyuan Qu, Xujia Huang, Jinqiao Mi, Xuzhi Chen, Bingbing Wu, Jian Xu. 2025-11-14. Education, socioeconomic status, leisure sedentary behaviors and female infertility: mendelian randomization study.. https://doi.org/10.1186/s12905-025-03849-2

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