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PubMed · 41206940

OpTiles: an R package for adaptive tiling and methylation variability profiling.

Giorgia Migliaccio·Lena Möbus·Giusy Del Giudice·Jack Morikka·Antonio Federico·Angela Serra·Dario Greco
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Abstract

SUMMARY: OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG density with intra-region methylation variability, it provides a reliability metric and extended functionality for annotating, prioritizing, and interpreting complex methylation data. AVAILABILITY AND IMPLEMENTATION: OpTiles is implemented in R and source code is freely available at https://github.com/fhaive/OpTiles. Data are available on Zenodo at https://doi.org/10.5281/zenodo.16961292.

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Giorgia Migliaccio, Lena Möbus, Giusy Del Giudice, Jack Morikka, Antonio Federico, Angela Serra, Dario Greco. 2025-11-01. OpTiles: an R package for adaptive tiling and methylation variability profiling.. https://doi.org/10.1093/bioinformatics%2Fbtaf614

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