Depressive behavior and hyperactive adrenocortical function.

J H Kocsis; J M Davis; M M Katz; S H Koslow; P E Stokes; R Casper; D E Redmond

doi:10.1176/ajp.142.11.1291

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Depressive behavior and hyperactive adrenocortical function.

J H Kocsis·J M Davis·M M Katz·S H Koslow·P E Stokes·R Casper·D E Redmond

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Abstract

This study examined relationships between depressive subtypes, clinical-behavioral characteristics, and hypothalamic-pituitary-adrenocortical (HPA) function in 132 hospitalized depressed patients. There were significant positive correlations between several pre- and postdexamethasone plasma cortisol measures and anxiety, psychomotor disturbance, distressed expression, and sleep disturbance. Few significant relationships were seen between illness severity and HPA function. Virtually no endocrine differences were seen between endogenous and nonendogenous subtypes or between psychotic and nonpsychotic subtypes. These results and the previous literature suggest a profile of depressed patients with HPA overactivation; they are likely to be anxious, to have sleep and psychomotor disturbances, to have lost weight in the current episode, and to be older.

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Adrenal Cortex Age Factors Anxiety Disorders Body Weight Depressive Disorder Dexamethasone Diagnosis, Differential Female Humans Hydrocortisone Hypothalamo-Hypophyseal System Male Middle Aged Pituitary-Adrenal System Psychiatric Status Rating Scales Psychomotor Disorders Sleep Wake Disorders Journal Article Research Support, U.S. Gov't, P.H.S.

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J H Kocsis, J M Davis, M M Katz, S H Koslow, P E Stokes, R Casper, D E Redmond. 1985. Depressive behavior and hyperactive adrenocortical function.. https://doi.org/10.1176/ajp.142.11.1291

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