Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 4034436

Collagenous colitis.

A Foerster·O Fausa
View original source ↗Export metadata ↓

Abstract

A clinical and morphological description of "collagenous colitis" with reference to own cases is given. The disease presents with watery diarrhoea and abdominal pain in middle aged subjects, mostly women. Clinical and laboratory findings are normal. In colo-rectal biopsies there is a severe thickening of the so called "collagen table" in the superficial inter-cryptal lamina propria. Ultrastructural examination shows bandlike subepithelial collagenous fibrils of types I and III. The etiology of this lesion in the large bowel is hitherto unknown. The clinical course seems to be rather benign, requiring only symptomatic treatment.

Explore related subjects

ColitisCollagenEpitheliumFemaleHistocytochemistryHumansImmunochemistryIntestinal MucosaIntestinesMicroscopy, ElectronMiddle AgedJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A Foerster, O Fausa. 1985. Collagenous colitis.. https://doi.org/10.1016/s0344-0338(85)80084-4

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2003

[Allergy-associated colitis. Characterization of an entity and its differential diagnoses].

There is substantial evidence that allergic reactions exist in the gastrointestinal tract (GI). However, patients with food allergy-related enteropathy pose a diagnostic challenge to physicians because the clinical features are variable, unspecific, occur in other gastrointestinal disorders, and specific diagnostic tools are missing. Several recent studies and reviews have focused on the function of eosinophilic granulocytes in GI disease. The role of eosinophils in the pathophysiology of GI hypersensitivity reactions is poorly defined. However, some findings have been reported that imply an involvement of eosinophils in allergic reactions of the gut. The presumptive histology of allergy-associated colitis in colonic and ileal biopsies is based on prominent pure eosinophilic infiltration of a normal lamina propria, submucosa and epithelium with variable degrees of degranulation. An immunoperoxidase stain for eosinophilic peroxidase is supportive in establishing the diagnosis if suspected. Neutrophils or mononuclear infiltrates are not significantly increased and damage to the intestinal tissue is not prominent. Despite characteristic histologic changes in colonic biopsy specimens, a final diagnosis depends on careful clinical examination and exclusion of several differential diagnoses.

Colitis↗