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PubMed · 40200803

Ectopic Gene Conversion Causing Quantitative Trait Variation.

Marina Pfalz·Seïf-Eddine Naadja·Jacqui Anne Shykoff·Juergen Kroymann
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Abstract

Why is there so much non-neutral genetic variation segregating in natural populations? We dissect function and evolution of a near-cryptic quantitative trait locus (QTL) for defense metabolites in Arabidopsis using the CRISPR/Cas9 system and nucleotide polymorphism patterns. The QTL is explained by genetic variation in a family of 4 tightly linked indole-glucosinolate O-methyltransferase genes. Some of this variation appears to be maintained by balancing selection, some appears to be generated by non-reciprocal transfer of sequence, also known as ectopic gene conversion (EGC), between functionally diverged gene copies. Here, we elucidate how EGC, as an inevitable consequence of gene duplication, could be a general mechanism for generating genetic variation for fitness traits.

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Quantitative Trait LociArabidopsisGene ConversionGenetic VariationCRISPR/Cas9ectopic gene conversionnucleotide polymorphism patternsquantitative genetic variationquantitative trait locusJournal Article

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Marina Pfalz, Seïf-Eddine Naadja, Jacqui Anne Shykoff, Juergen Kroymann. 2025-04-30. Ectopic Gene Conversion Causing Quantitative Trait Variation.. https://doi.org/10.1093/molbev%2Fmsaf086

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