Decrease of choline acetyltransferase activity of rat cortex capillaries with aging.

F F Santos-Benito; J L Gonzalez

doi:10.1111/j.1471-4159.1985.tb04034.x

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Decrease of choline acetyltransferase activity of rat cortex capillaries with aging.

F F Santos-Benito·J L Gonzalez

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Abstract

Choline acetyltransferase (ChAT) activity was estimated in brain cortex capillaries isolated from 3-, 12-, 18-, and 24-month-old rats. Maximum enzymatic activity was found at 12 months (55 +/- 0.3 pmol X mg-1 protein X min-1; mean +/- SEM) and then it decreased to reach a minimum at 24 months (34 +/- 3.1 pmol X mg-1 protein X min-1). A less marked decrease of enzymatic activity was also found in cortex homogenate and in a synaptosomal fraction obtained from the same groups of rats. Loss of ChAT of brain capillaries with aging could be related to a general phenomenon of cortical cholinergic deficit in that condition.

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Aging Animals Brain Capillaries Choline O-Acetyltransferase Male Microscopy, Electron Rats Rats, Inbred Strains Synaptosomes Journal Article

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F F Santos-Benito, J L Gonzalez. 1985. Decrease of choline acetyltransferase activity of rat cortex capillaries with aging.. https://doi.org/10.1111/j.1471-4159.1985.tb04034.x

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