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PubMed · 40081792

Peering into the Bacterial Cell: From Transcription to Functional Genomics.

Carol A Gross
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Abstract

I started my faculty career in 1981 at the UW-Madison in the Department of Bacteriology and moved to the University of California, San Francisco in 1993, where I am a Professor in the Departments of Microbiology and Immunology and Cell and Tissue Biology. In this article, I first review my contributions to understanding the molecular biology of the bacterial transcriptional apparatus and the global role of alternative sigmas (σs), a major pillar of bacterial transcriptional control. I then discuss my role in spearheading the development of bacterial systems biology, specifically to the genome-wide phenotyping approaches necessary for rapid understanding of gene function and the molecular basis of pathway connections across the bacterial universe.

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GenomicsTranscription, GeneticBacteriaHistory, 20th CenturyHistory, 21st CenturyGene Expression Regulation, BacterialSystems BiologyCRISPRibacterial functional genomicsbacterial transcriptionheat shock responsesigmasJournal ArticleHistorical ArticleReviewResearch Support, N.I.H., Extramural

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Carol A Gross. 2025-03-11. Peering into the Bacterial Cell: From Transcription to Functional Genomics.. https://doi.org/10.1016/j.jmb.2025.169087

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