PubMed · 3973478
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R Tiwari. 1985. Reconstruction after temporal bone resection.. https://doi.org/10.1017/s0022215100096420
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
BACKGROUND: Postgastrectomy patients undergoing chemoradiation risk chemoradiation-induced liver disease (CRILD). The objectives of this study were to investigate dosimetric implications and assess biologic susceptibility to CRILD in these patients. METHODS: Sixty-two patients with Stage IB-IV gastric/gastroesophageal adenocarcinoma without metastases underwent radical total/subtotal gastrectomy; regional lymph node dissection; and postoperative, adjuvant, concomitant chemoradiotherapy (CCRT). Among these, 8 patients developed CRILD (defined as Grade 3-4 liver toxicity), and 11 patients were chronic hepatitis B virus (HBV) carriers (HBV+). Chemotherapy consisted of 1 cycle of etoposide, leucovorin, and 5-fluorouracil (ELF); followed by 5 weekly high doses of 5-fluorouracil (2000-2600 mg/m2) and leucovorin concurrent with radiotherapy (median dose, 45 grays [Gy] to the tumor bed/regional lymphatics); followed by 3 cycles of ELF separated by a 21-day interval. Patients were followed for > or = 4 months after CCRT. Patient-related and dosimetric factors were correlated with CRILD. RESULTS: HBV+ status was the only independent factor associated with CRILD. HBV+ patients had a higher CRILD incidence (6 of 11 patients vs. 2 of 51 patients; P < 0.001). HBV-negative patients with CRILD were recipients of a higher mean liver dose (MLD) (23.8 Gy vs. 15.2 Gy; P = 0.009) and a higher volume fraction of liver that received > 30 Gy (36.5% vs. 19.7%; P = 0.009) compared with noncarriers without CRILD, but no MLD difference was found between HBV+ patients with or without CRILD. Moreover, in four of six carriers with CRILD, HBV infection was reactivated during CRILD. Two of the toxicities were fatal. CONCLUSIONS: HBV carriers had a higher incidence of CRILD after postgastrectomy CCRT, probably related to HBV reactivation. Dosimetric parameters modulated the risk of CRILD in noncarriers, but not in carriers. These factors deserve attention in CRILD/HBV+ patients, and the underlying pathogenesis warrants investigation.
OBJECTIVE: Integration between psychotherapy and psychopharmacotherapy has been a conflicting subject in the history of psychiatry. To date, dichotomy between "biological" and "psychological" models is noticed, although recent studies have been showing the importance of the association of these modalities in the current psychiatric practice. This study attempts to review psychodynamic, technical, and other issues involving the integration of pharmacological and psychotherapeutical treatments. METHODS: Literature search was based on MEDLINE, PsychoINFO and Lilacs, referring to the period from 1966 to September 2002. RESULTS: The studies reviewed demonstrated that the application of combined treatment might be positive. CONCLUSIONS: The efficacy of the combined treatment depends on the capacity of the integration of the different forms of treatment. More research is necessary in this area.