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PubMed · 371344

Kidney function in acromegaly.

P C Eskildsen·H H Parving·C E Mogensen·J S Christiansen
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Abstract

Creatinine clearance and daily urinary albumin and beta2-microglobulin excretion rates (radio-immunoassays) were measured several times in 14 patients with acromegaly. Eleven patients were treated with bromocriptine, 5 to 55 mg/day. The activity of the disease was assessed by measuring urinary growth hormone excretion (radio-immunoassay). In agreement with previous investigations we found the creatinine clearance elevated. However, no correlation was found between this variable and urinary growth hormone excretion. Urinary albumin and beta 2-microglobulin excretion rates were not significantly different from our previous results in 27 adults control subjects. There was no correlation between urinary growth hormone excretion and urinary albumin or beta 2-microglobulin excretion rates. Bromocriptine treatment reduced urinary growth hormone excretion from 220 to 91 ng/24 hours, p less than 0.01, but no significant alterations were induced in the above mentioned kidney function variables.

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AcromegalyAdultAgedAlbuminuriaBromocriptineCreatinineFemaleGlomerular Filtration RateGrowth HormoneHumansKidneyMaleMiddle Agedbeta 2-MicroglobulinJournal Article

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P C Eskildsen, H H Parving, C E Mogensen, J S Christiansen. 1979. Kidney function in acromegaly.. https://doi.org/10.1111/j.0954-6820.1979.tb00724.x

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