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PubMed · 3606142

[Recent progress in oncogene studies].

K Toyoshima
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Abstract

Oncogene studies have become an area of general interest in the field of cancer research following the identification of the cellular counterparts of viral oncogenes. It may be possible to attribute some steps in the initiation or progression of cancer to point-mutations or altered expression of proto-oncogenes. Elucidation of the normal functions of proto-oncogene products as growth factors, growth factor receptors or other growth regulatory elements will facilitate biochemical analysis of the mechanisms of normal and malignant cell growth.

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Genes, ViralHumansNeoplasmsOncogenesProto-Oncogene MasProto-OncogenesJournal Article

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BibTeXRIS

K Toyoshima. 1987. [Recent progress in oncogene studies].. https://pubmed.ncbi.nlm.nih.gov/3606142/

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In this study, we analyzed the influence of two nested genes (p19 and p22) of tomato bushy stunt virus (TBSV) on disease symptoms in systemically infected plants and in local lesion hosts. The contribution of individual genes was determined by bioassays with an infectious clone of wild-type TBSV, with p19/p22 mutant derivatives, and by expression of individual TBSV genes from a heterologous potato virus X (PVX) vector. Our results showed that TBSV genes could be expressed at high levels from the PVX vector. The subcellular localization of these proteins as well as the ability of PVX-expressed p22 to trans complement TBSV cell-to-cell movement defective mutants indicate that the exogenously expressed proteins are functionally active. Inoculation studies with TBSV mutants and the PVX derivatives demonstrated that p19 induced a generalized necrosis upon systemic infection of Nicotiana benthamiana and N. clevelandii. In addition, p19 elicited the formation of local necrotic lesions in N. tabacum; however, in N. glutinosa and N. edwardsonii, the local lesion response was activated by p22. These results show that the p19 and p22 proteins of TBSV are important symptom determinants and that closely related plant species may contain different resistance genes that selectively respond to individual TBSV proteins.

Genes, Viral↗