PubMed · 3568334
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1987. Calcium-entry blockage: basic concepts and clinical implications.. https://pubmed.ncbi.nlm.nih.gov/3568334/
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Photodegradation products of hexahydroquinoline derivatives (HHQ) have been analysed with gas chromatography-mass spectrometry (GC-MS). The photodegradation was carried out under the conditions recommended in the first version of the document issued by the International Conference on Harmonization (ICH), currently in force in the studies of photochemical stability of drugs and therapeutic substances. The study was performed on the compounds having two chlorine atoms at different positions of the phenyl ring. Photodegradation of dichlorophenyl derivatives of HHQ resulted in formation of one or three photoproducts. The main product of their decomposition was aromatic compound formed as a result of dehydrogenation of the dihydropyridine ring. The most often observed fragmentation pathway of the photoproducts formed was elimination of methyl and methoxy radicals from the ester groups. The fragmentation of the photoproducts containing one chlorine atom at the ortho-position of the phenyl ring occurred through elimination of chlorine radical.
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CONTEXT: Little is known about the crosstalk between the decidua and myometrium in relation to human labor. The hormone oxytocin (OT) is considered to be a key mediator of uterine contractility during parturition, exerting some of its effects through calcium channels. OBJECTIVE: The objective was to characterize the effect of OT on the T-type calcium channel in human decidual stromal cells before and after the onset of labor. DESIGN: The nystatin-perforated patch-clamp technique was used to record inward T-type calcium current (I(Ca(T))) from acutely dispersed decidual stromal cells obtained from women at either elective cesarean section [CS (nonlabor)] or after normal spontaneous vaginal delivery [SVD (labor)]. SETTING: These studies took place at the University of Nottingham Medical School. RESULTS: I(Ca(T)) of both SVD and CS cells were blocked by nickel (IC(50) of 5.6 microm) and cobalt chloride (1 mm) but unaffected by nifedipine (10 microm). OT (1 nm to 3.5 microm) inhibited I(Ca(T)) of SVD cells in a concentration-dependent manner, with a maximal inhibition of 79.0% compared with 26.2% in decidual cells of the CS group. OT-evoked reduction of I(Ca(T)) was prevented by preincubation with the OT antagonist L371,257 in the SVD but not CS group. OT, in a concentration-dependent manner, displaced the steady-state inactivation curve for I(Ca(T)) to the left in the SVD group with no significant effect on curves of the CS group. CONCLUSION: Inhibition of I(Ca(T)) by OT in decidual cells obtained during labor may signify important functional remodeling of uterine signaling during this period.